The administration of pilocarpine has been shown to increase tissue levels of specific proteins in several biological systems, possibly by exerting an effect on protein synthesis. Litarczek has shown that the administration of pilocarpine causes an increased antibody production in rabbits given inoculations of typhus bacillus (6), and recent investigations have indicated that an in creased accu...

Salter, De Meyer, and Best (6) recently reported that giving glucagon to Wistar rats bearing the Walker 256 adenocarcinoma significantly retarded growth of the tumor. I t was therefore thought to be of interest to see whether this effect of glucagon was exerted on another kind of rat tumor and on an isologous tumor in a pure strain of mice and, if so, to determine whether the effect observed is...

This presentation is based on our experience with tumor marker monitoring of surgery therapy and chemotherapy effects. The control of chemotherapy is one of the most important problems in oncological practice. The correlation between the clinical status of the patient and tumor size changes, based on the results of different imaging methods, has been the most important and most frequently used ...

PET has the invaluable advantage of being intrinsically quantitative, enabling accurate measurements of tracer concentrations in vivo. In PET tumor imaging, indices characterizing tumor uptake, such as standardized uptake values, are becoming increasingly important, especially in the context of monitoring the response to therapy. However, when tracer uptake in small tumors is measured, large bi...

The effect of hydrocortisone acetate (HCA) on three cell lines of Ehrlich ascites tumors was investigated in four strains of mice. It was attempted to separate the immunological aspects from the hormonal influence in the cortisone treatment of the tumors. HCA significantly inhibited the growth of ascitic hypotetraploid Ehrlich stock in Swiss mice, and to a lesser extent that of ascitic hypotetr...

Tumor cells develop different features to adapt to environmental conditions. A prominent example is the ability of tumor cells to switch between migratory and proliferative phenotypes, a phenomenon known as go-or-grow mechanism. It is however unclear how this particular phenotypic plasticity affects overall tumor growth. To address this problem, we formulate and study a mathematical model of sp...

The anti-tumor effect of immunization with heat-killed Mycobacterium tuberculosis (Tbc) and Tuberculin (PPD)-coupled syngeneic tumor cells was examined in vivo. Three tumor cell lines were employed. Immunization of Tbc-primed BALB/c mice with PPD-coupled syngeneic Meth-A tumor cells displayed a potent anti-tumor effect on viable Meth-A cells inoculated subcutaneously. Neither PPD-coupled LLC (L...

Abstract Background Treatment options for recurrent glioblastoma are limited and with the possible exception of regorafenib, no agent has demonstrated superior activity to lomustine. Therefore, there is an urgent need more effective treatment strategies glioblastoma. Here, we investigated different combinations based on tumor-stroma targeting antibody-cytokine fusion protein L19TNF in preclinic...

background: inhibin is a dimeric glycoprotein that has a depressive effect on the anterior hypophyse secretion. the level of this tumor marker is undetectable in menopause women. in patients with gynecological cancer, especially granulosa and epidermal-type (mucinous), ovarian cancers considerable increase in the serum level of inhibin has been reported. the increased level of inhibin has been ...

cancer stem cells (csc) are the tumor-associated cells existed within tumors or hematological cancers which share characteristics similar to normal stem cells. the common characteristics of a normal stem cell and a csc are their differentiation capacity and self-renewal in tumors. the expression pattern of csc markers differs depending on the type and location of cancers. cd molecules are proba...