The combination of Dacarbazine (DTIC) with alphainterferon has consistently shown a 30% remission rate in patients with disseminated malignant melanoma (Thomson et al., 1987; Guillou et al., 1989; Mulder et al., 1990). Although some of these remissions, in particular the complete remissions are prolonged, overall results are not satisfactory. Recently, a synergistic effect has been described be...

Two parallel and concordant activities characterize cell cycle progression. One is associated with preparation for and execution of DNA replication followed by mitosis (" cell cycle "). Cyclins are the motors of the cell cycle, as they activate the respective CDKs and thereby drive the cell through the sequential phases of the cycle. Their antagonists are CKis, which inhibit the CDKs stalling t...

The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then syst...

Over the last decades, accumulating data have advanced our understanding of the mechanism of action of tumor suppressor proteins and therapeutic strategies to restore tumor suppressor pathways have emerged as a promising approach for cancer therapy. Based on our recent findings on bridging integrator-1 (BIN1), we outline potential advantages and disadvantages of chemical activation of tumor sup...

Preparing the books to read every day is enjoyable for many people. However, there are still many people who also don't like reading. This is a problem. But, when you can support others to start reading, it will be better. One of the books that can be recommended for new readers is tumor suppressor genes in human cancer. This book is not kind of difficult book to read. It can be read and unders...

background: in 1997 mmac1 or the pten gene, was identified as a tumor suppressor gene on the long arm of chromosome 10.pten involves in the balance between proliferation, and differentiation, apoptosis and regulation of angiogenesis, and eventually mutation in this gene causes a strong potential for tumorigenesis cells. this study is the first report of the correlation between pten gene mutatio...

Abstract The Wilms' tumor 1 (WT1) gene is well known as a chameleon gene. It plays role suppressor in but also acts an oncogene other cancers. Previously, our group reported that canonical AUG starting site for the WT1 protein (augWT1) suppressor, whereas CUG (cugWT1) functions oncogene. In this study, we report oncogenic of cugWT1 AOM/DSS-induced colon cancer mouse model and urethane-induced l...

C ancer cells become far more dangerous when they gain the ability to metastasize and colonize other parts of the body. But to start moving, the rogue cells have to break away from their neighbors. Walter Birchmeier (now at the Max-Delbrück-Center of Molecular Medicine in Berlin, Germany) and colleagues discovered how, showing that some cancer cells down-regulate a surface receptor that locks a...