نتایج جستجو برای: tumor suppressors
تعداد نتایج: 430979 فیلتر نتایج به سال:
The Scrib module proteins, Scrib, Dlg, and Lgl, are conserved regulators of cell polarity in diverse biological contexts. Originally discovered as neoplastic tumor suppressors the fruit fly Drosophila melanogaster, disruption components leads to tumorigenesis mammalian epithelia is associated with human cancers. With multiple protein interacting domains, proteins function determinants basolater...
Discovery of targeted therapies that selectively exploit the genetic inactivation specific tumor suppressors remains a major challenge. This includes prevalent deletion CDKN2A/ MTAP locus, which was first reported nearly 40 years ago. The more recent advent RNA interference and functional genomic screening technologies led to identification hidden collateral lethalities occurring with passenger...
multiple myeloma (mm), is the second most common blood cancer after non-hodgkin’s lymphoma. genetic changes, structural and numerical chromosome anomalies, are involved in pathogenesis of mm, and are among the most important prognostic factors of disease-associated patient survival. micrornas (mirnas) are small 19-22 nucleotide single-stranded rnas involved in important cellular processes. cyto...
Cancer is a complex pathology characterized by aberrant cell proliferation, resistance to induced cell death, and tumoral cell capacity to leave initial tissue and form distant tumors (metastasis). In addition, cancer cells favor angiogenesis which is necessary for tumor survival, progression and dissemination. Genetic events leading to genome instability enable those cell deregulations, in par...
We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(INK4C) resulted in impaired cell-cycle progression and tumorigenic potential. Conversely, RNAi-medi...
An enormous amount of tumor sequencing data has been generated through large scale sequencing efforts. The functional consequences of the majority of mutations identified by such projects remain an open, unexplored question. This problem is particularly complicated in the case of rare mutations where frequency of occurrence alone or prediction of functional consequences are insufficient to dist...
Several hallmarks of cancer cells are their display of metabolic changes and enhanced proliferation. Highly proliferating cells utilize glutamine as a source of nitrogen, and therefore, one of the commonly seen metabolic changes is increased glutaminolysis, or glutamine catabolism. In addition, glutamine is an important anaplerotic source by which cells support the pools of TCA cycle intermedia...
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