We have studied the dose-response relationships for neostigmine and edrophonium during antagonism of neuromuscular block induced by mivacurium chloride. Sixty-four ASA group I or II adults were given mivacurium 0.15 mg kg-1 during fentanyl-thiopentone-nitrous oxide-isoflurane anaesthesia. Train-of-four stimulation (TOF) was applied to the ulnar nerve every 10 s, and the force of contraction of ...

The force produced by cat muscles over time with two stimuli separated by a short interval is approximately three times that produced by a twitch of cat muscles. This facilitation of force production by a second stimulus involves both increases in magnitude and duration of the contraction. Increased magnitude is relatively more important in the fast-twitch plantaris muscle, whereas increased du...

Structural and physiological mechanisms underling functional adaptations of a muscle to chronic whole-body vibration (WBV) are poorly understood. The study aimed at examining the contractile properties of motor units and the myosin heavy chain (MHC) expression in rat medial gastrocnemius muscle in response to 3- or 6-month periods of the WBV. The three-month WBV induced modifications of contrac...

10.1128/MCB.24.14.6253-6267.2004. 2004, 24(14):6253. DOI: Mol. Cell. Biol. Pascal Maire Petrof, Dominique Daegelen, Jean-Paul Concordet and Kiyoshi Kawakami, Pin-Xian Xu, Robert Kelly, Basil J. Lopez, Josiane Demignon, Jacques-Emmanuel Guidotti, Raphaelle Grifone, Christine Laclef, François Spitz, Soledad Phenotype into the Fast-Twitch Phenotype Adult Muscle from the Slow-Twitch Six1 and Eya1 E...

The ferret has become a popular model for physiological and neurodevelopmental research in the visual system. We believed it important, therefore, to study extraocular whole muscle as well as single motor unit physiology in the ferret. Using extracellular stimulation, 62 individual motor units in the ferret abducens nucleus were evaluated for their contractile characteristics. Of these motor un...

BACKGROUND To examine the hypothesis that forearm pain with palpation tenderness in computer users is associated with increased extensor muscle fatigue. METHODS Eighteen persons with pain and moderate to severe palpation tenderness in the extensor muscle group of the right forearm and twenty gender and age matched referents without such complaints were enrolled from the Danish NUDATA study of...

Abdominal muscles are the most important expiratory muscles for coughing. Spinal cord-injured patients have respiratory complications because of abdominal muscle weakness and paralysis and impaired ability to cough. We aimed to determine the optimal positioning of stimulating electrodes on the trunk for the noninvasive electrical activation of the abdominal muscles. In six healthy subjects, we ...

Little is known about how human motor units respond to chronic paralysis. Our aim was to record surface electromyographic (EMG) signals, twitch forces, and tetanic forces from paralyzed motor units in the thenar muscles of individuals (n = 12) with chronic (1.5-19 yr) cervical spinal cord injury (SCI). Each motor unit was activated by intraneural stimulation of its motor axon using single pulse...

WEBB, GEORGE Il. Efects of surfactants on the twitch tension uf frog sartorius muscle. Am. J. Physiol. 207(2) : 397-401. 196+--Many types of cells show permeability increases to ions and to various uncharged molecules when exposed to surface-active agents (surfactants) . Nonionic surfactants are less effective than ionic surf’actants in increasing permeability and in depolarizing nerve and musc...