INTRODUCTION Severe hypoglycemia is a burden for both patients and the healthcare system payer alike. This study aimed to quantify the resource use associated with a severe hypoglycemic event (SHE) in patients with diabetes. METHODS This retrospective cohort study compared resource use (e.g., physician visits, hospitalizations, and medications) 1 month pre- and post-SHE among patients with ty...

abstract background: an association of eating disorder with diabetes mellitus may lead to a serious lack of metabolic control, higher mortality and morbidity. there is no recent study conducted in the iranian population about eating disorder and its variants. the aim of the present study is investigation of frequency of disturbed eating behaviors in adolescent girls with type 1 diabetes mellitu...

For individuals with type 1 diabetes (T1D), minimizing exposure to hyperglycaemia (high glucose), is key in preventing microvascular complications, such as retinopathy, neuropathy and nephropathy. Chronic hyperglycaemia may also contribute to the development of cognitive deficit as reported in groups with T1D when compared to healthy controls [1]. However, some researchers maintain that it is t...

Macrophages are early islet-infiltrating cells seen in type 1 diabetes (T1D). While proinflammatory M1 macrophages induce T1D, M2 macrophages have been shown to delay this autoimmune disease in nonobese diabetic (NOD) mice, but the environmental cues that govern macrophage polarization and differentiation remain unresolved. We previously demonstrated the importance of reactive oxygen species (R...

Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β cells, resembling that observed during pancre...

Type 1 diabetes (T1D) is characterized by hyperglycemia due to lost or damaged islet insulin-producing β -cells. Rodent models of T1D result in hyperglycemia, but with different forms of islet deterioration. This study focused on 1 toxin-induced and 2 autoimmune rodent models of T1D: BioBreeding Diabetes Resistant rats, nonobese diabetic mice, and Dark Agouti rats treated with streptozotocin. I...

BACKGROUND The autoimmune disease type 1 diabetes mellitus (T1D) is associated with a defect in the immune response, which increases susceptibility to infection. We recently demonstrated that prolonged elevated levels of type 1 interferon (IFN) induce lymphocyte exhaustion during T1D. AIMS In the present study, we further investigated the effect of blocking the type I IFN receptor signaling p...

OBJECTIVE Alexithymia refers to difficulty in identifying and expressing emotions, and it is a characteristic common to several psychiatric and medical conditions, including autoimmune disorders. Type 1 diabetes (T1D) is an autoimmune disorder with increased psychiatric comorbidity. Previously reported associations between alexithymia and T1D may have been confounded by the presence of depressi...

In the field of management it has long been recognised that effective management of any given outcome requires knowledge and control of inputs to the system. This is also true in healthcare particularly in Type 1 diabetes (T1D), a common and severe chronic disease in childhood which is a huge health, social and economic burden 1,2 . In T1D the outcome, in terms of prevention of diabetes related...