Benthic egg masses laid in intertidal habitats are exposed to numerous environmental stresses including potentially damaging ultraviolet radiation (UVR). We sought to determine the developmental effects of UVR and visible light on molluscan embryos within egg masses from habitats with differential UVR exposure. Capsular and gelatinous egg masses from 23 marine gastropod species were collected f...

RNA polymerase II (RNAPII) acts as a damage sensor for transcription-coupled nucleotide excision repair (TC-NER) and undergoes proteolytic clearance from damaged chromatin by the ubiquitin-proteasome system (UPS). Here, we report that Valosin-containing protein (VCP)/p97, a druggable oncotarget, is essential for RNAPII's proteolytic clearance in mammalian cells. We show that inhibition of VCP/p...

The metabolic balance of the most extensive bioma on the Earth is a controversial topic of the global-change research. High ultraviolet radiation (UVR) levels by the shoaling of upper mixed layers and increasing atmospheric dust deposition from arid regions may unpredictably alter the metabolic state of marine oligotrophic ecosystems. We performed an observational study across the south-western...

Exposure to ultraviolet radiation (UVR) is a significant risk factor for age-related cataract, a disease of the human lens and the most prevalent cause of blindness in the world. Cataract pathology involves protein misfolding and aggregation of the primary proteins of the lens, the crystallins. Human γD-crystallin (HγD-Crys) is a major γ-crystallin in the nucleus of the human lens. We report he...

BACKGROUND Cataracts are one of the major public health problems worldwide. Ultraviolet radiation (UVR) is one of the risk factors for cataract development. We analyzed the relationship between disability-adjusted life year (DALY) rates of cataracts and UVR exposure in China. METHODS DALY rates of cataracts and UVR exposure in 31 regions of China were calculated based on data from the Second ...

In toto, there is strong circumstantial evidence from both experimental and clinical studies to support a role for omega-3 FA in the prevention of non-melanoma skin cancer (NMSC). In experimental animal studies there is direct evidence that dietary omega-3 FA inhibits ultraviolet radiation (UVR) carcinogenic expression, with regard to both increased tumor latent period and reduced tumor multipl...

Ultraviolet radiation (UVR) is among major contributors to skin cancer in humans. Production of melanin serves as a main defense mechanisms against UVR damage. This pigment, which gives color hair, and eyes, protects the underlying tissue from However, some patient populations, this protection mechanism not effective, leaving patients highly susceptible cancer. Similarly, mycosporine like amino...

The work has been carried out at Department of Dermatology, H:S Bispebjerg Hospital, Copenhagen. The main objective of the project was to explore, if the skin and the eye lens could be used as biological Ultraviolet Radiation (UVR) dosimeters. Solar UVR exposure is an important risk factor for development of skin cancer. A usable method for monitoring individual UVR exposure is therefore prereq...

Slug (Snai2), a highly conserved transcriptional repressor important in epithelialmesenchymal transformation (EMT) in development, has also been implicated in EMT-like processes during tumor progression (Hemavathy et al., 2000). Slug null mice chronically exposed to ultraviolet radiation (UVR) develop a lower skin tumor burden than wild type mice, with fewer aggressive spindle cell tumors (Newk...

A certain degree of solar light illuminance could prevent myopia in children. However, UV radiation (UVR) serves as mutagen and a non-specific damaging agent. Ultraviolet can initiates promote tumor growth, essentially under the skin. To this end, study was designed to assess daily annual UVR exposures outdoor workers (OWs) Southwestern Nigeria by using standard methods. Results obtained show t...