Mechanical stimulation is known to regulate the calcification of endplate chondrocytes. The ANK protein has a strong influence on anti-calcification by transports intracellular inorganic pyrophosphate (PPi) to the extracellular. It is known that TGF-β1 is able to induced Ank gene expression and protect chondrocyte calcification. Intermittent cyclic mechanical tension (ICMT) could induce calcifi...

High-throughput screening techniques for cellular response are often unable to account for several factors present in the in vivo environment, many of which have been shown to modulate cellular response to the screened parameter. Culture in three-dimensional biomaterials and active mechanical stimulation are two such factors. In this work, we integrate these microenvironmental parameters into a...

This work aims to investigate different predictive models for estimating the unconfined compressive strength and maximum peak strain of non-structural recycled concretes made up by ceramic concrete wastes. The extensive experimental campaign carried out during this research includes granulometric analysis, physical chemical compression tests along with use 3D digital image correlation as a meth...

the hot compression tests were carried on x45crniw189 valve steel (x45) in the temperature rangeof 1000– 1200 °c and the strain rate range of 0.004 – 0.5 s-1 in order to study the high temperaturesoftening behavior of this steel. for the exact prediction of flow stress, the effective stress-effectivestrain curves were obtained from experiments under various conditions. on the basis of experimen...

The development and utilization of three-dimensional cell culture platforms has been gaining more traction. Three-dimensional culture platforms are capable of mimicking in vivo microenvironments, which provide greater physiological relevance in comparison to conventional two-dimensional cultures. The majority of three-dimensional culture platforms are challenged by the lack of cell attachment, ...

objective: in this paper, finite element model of the l4 vertebra subjected to combination of compression and flexion loading in isotropic and anisotropic cases is investigated. methods: in both cases, the vertebra is considered homogeneous. also, the body of vertebra is divided to cancellous and cortical sections in anisotropic model, but the process is assumed isotropic such as isotropic mode...

Many petrophysical properties (e.g. permeability, electrical resistivity etc.) of tight rocks are very stress sensitive. However, most mercury injection measurements are made using an instrument that does not apply a confining pressure to the samples. Here we further explore the implications of the use and analysis of data from mercury injection porosimetry or mercury capillary pressure measure...

Poly(vinyl alcohol) (PVA) hydrogels have been proposed as promising biomaterials to replace diseased or damaged articular cartilage. A critical barrier to their use as load-bearing tissue replacements is a lack of sufficient mechanical properties. The purpose of this study was to characterize the functional compressive and shear mechanical properties of a novel PVA hydrogel. Two formulations of...

Introduction: A majority of the mountains on Io are tectonic, upthrusted blocks [1-8]. The mechanism behind their formation, however, is unknown. Mountain formation may be indirectly related to the prolific volcanism on Io [3]. Three major mountain formation hypotheses following from this idea include: • convection-modified subsidence: global compressional stresses (subsidence) are created by t...