OBJECTIVES We evaluated the effect of an angiotensin-converting enzyme inhibitor (enalapril) on renal function during and after the relief of partial unilateral ureteric obstruction (UUO). MATERIALS AND METHODS Thirty-two male mongrel dogs were classified into three groups: sham (eight), control (12; left partial UUO + no medication) and study (12; left partial UUO + enalapril). Dogs in the s...

Simple Nephrectomy is a standard therapeutic urological procedure for irreversibly damaged non functioning kidneys involved by different benign pathological conditions like extensive renal stone disease, obstruction due to impacted calculus in the kidney or ureter,trauma,nephrosclerosis,neglected pelviureteric junction obstruction(PUJO),congenital malformations, renovascular hypertension due to...

Most chronic kidney disease in infants and children results from congenital anomalies of the kidneys and urinary tract, including obstructive nephropathy. Although less common, inherited disorders such as polycystic kidney disease (PKD) and cystinosis also lead to progressive tubular injury and nephron loss. At the present time, therapies to slow progression of kidney disease are mainly directe...

A variety of pelvic, retroperitoneal or metastatic malignancies may cause ureteral obstruction either by direct invasion or external compression of the ureter. Ureteral obstruction is a cause of significant morbidity and mortality in cancer patients these patients may suffer from acute or chronic pain, acute renal failure or subacute impairment of renal function, and they are at risk for infect...

beta-Catenin functions as a transducer of Wnt signals to the nucleus, where it interacts with the T cell factor (TCF) family of DNA binding proteins to regulate gene expression. On the basis of the genes regulated by beta-catenin and TCF in various biologic settings, two predicted functions of beta-catenin/TCF-dependent transcription are to mediate the loss of epithelial polarity and to promote...

Chronic kidney disease (CKD) poses a serious threat to the quality of human life and health with an increasing incidence worldwide. Renal fibrosis is closely related to CKD and regarded as the final common pathophysiological pathway in most cases of end-stage renal diseases. Elucidating the mechanisms underlying renal fibrosis and developing novel therapeutic strategies are of great importance....