Pruritus intensity is often not proportional to disease severity in patients with psoriasis or other pruritic dermatoses. Increasing evidence indicates that psychological factors may play an important role in the overall aetiology of pruritus. The aim of this study was to examine whether patients with psoriasis and severe pruritus differ psychologically from those with mild pruritus. In this st...

Post-burn pruritus is a common distressing consequence of burn wounds. Empirical treatment often fails to have a satisfactory outcome on post-burn pruritus, as the mechanism of post-burn pruritus has not been fully elucidated. The aim of this study was to evaluate the manifestation of transient receptor potential (TRP) channels in post-burn pruritus. Fifty-one burn patients with (n=33) or witho...

To evaluate the effects of kidney-pancreas transplantation on hemostatic abnormalities in uremic type 1 diabetic patients, we conducted a cross-sectional study involving 12 type 1 diabetic patients, 30 uremic type 1 diabetic patients, 27 uremic type 1 diabetic patients who had a kidney-pancreas transplant, 12 uremic type 1 diabetic patients who had a kidney-alone transplant, and 13 healthy cont...

Introduction A validated assessment of pruritus intensity is an important but still difficult clinical problem due to a subjective nature of this sensation. Objective The aim of this study was the creation and validation of new itch severity questionnaire assessing pruritus intensity. Material and Methods A total of 148 patients with pruritic dermatoses were asked to assess pruritus intensi...

Introduction Pruritus, which is restricted to segments of the body and unassociated with a rash, has been described in the literature under terms such as notalgia paraesthetica and brachioradial pruritus. Notalgia paraesthetica usually presents with pruritus around the shoulder blade area, and its dermatomal innervations are located between thoracic spinal nerves T2 and T6. Brachioradial prurit...

Limited studies indicate increased free fraction of valproic acid in uremia. One study also described displacement of valproic acid from protein binding by salicylate in children with epilepsy. The authors studied in vitro interaction of valproic acid and salicylate in uremic sera and compared their results with same interactions in normal sera. As expected, the concentrations of free valproic ...

Few studies have described therapeutic options in brachioradial pruritus. We describe a cross-sectional study of brachioradial pruritus patients treated in an outpatient unit. We reviewed medical records and interviewed brachioradial pruritus patients without indication for decompressive surgery, in order to access the perceptions of intensity of pruritus prior to treatment and response to ther...

BACKGROUND Pruritus is a common cutaneous manifestation of chronic kidney disease (CKD). It is associated with poor sleep quality, anxiety and depression which may contribute to reduction in quality of life (QoL). Paying more attention to pruritus in CKD patients may improve their QoL, reduce kidney disease burden and mortality. This study determined the prevalence, pattern and association of p...