In Saccharomyces cerevisiae, the degradation of urea to carbon dioxide and ammonia is catalyzed by urea carboxylase and allophanate hydrolase. The loci coding for these enzymes (dur1 and dur2) are very tightly linked on the right arm of chromosome II between pet11 and met8. Pleiotropic mutations that fail to complement mutations in either of the dur loci were found to be predominantly located i...

A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...

In recent years m u c h information has been gained on the s t ructure of the contracti le proteins in muscle and of the myofibril. Relat ively little, however, has been learned concerning the assembly and turnover of this organelle in l iving str iated muscle. The present studies were undertaken to de termine whether in the adul t an ima l the myofibril turns over as a uni t or whether the ind...

Plasma, obtained from rabbits given injections of urethan 2J hours previously, when administered intraperitoneally to Swiss mice, produced a significantly increased inci dence of lung adenomas in these animals, as well as an increased incidence of skin papillomas at the site of subsequent croton oil applications. These effects were not obtained when the plasma was lyophilized or desiccated, wit...

OBJECTIVE To describe characteristics associated with inappropriate hospital use by patients in Manitoba in order to help target concurrent utilization review. Utilization review was developed to reduce inappropriate hospital use but can be a very resource-intensive process. DESIGN Retrospective chart review of a sample of adult patients who received care for medical conditions in a sample of...

Studies on the deoxyribonucleic acid (DNA) content of normal nondividing plant and animal nuclei revealed that it is quite stable in interphase, showing little variation from cell to cell (4, 21). This is in sharp contrast to the wide varia tion and generally larger amounts of DNA found in tumor cells (1,17, 20,31) and normal cells dur ing periods of rapid growth (32). Preliminary ex periments ...

The finite element method with nonuniform mesh sizes is employed to approximately solve elliptic boundary value problems in unbounded domains. Consider the following model problem: -Am ■ / in Qc, u = g on 3ß, -~+ u = ol ] as r — |jc| -» oo, where ßc is the complement in R 3 (three-dimensional Euclidean space) of a bounded set il with smooth boundary 3Í2, / and g are smooth functions, and / has ...

Swedish patent litigation in comparison to European. Access to the published version may require subscription. Introduction A first large-scale systematic comparison of patent litigation across European jurisdictions was published in 2013 by Cremers et al., with data from Germany, UK (England and Wales), France and the Netherlands. 1 We have developed comparable statistics for Swedish patent ca...

T H E I N T E R S T A T E M O V E M E N T of industr ia l workers has long been an accepted factor in our American economy. I n the nineteenth century Paul B u n y a n , the m y t h i c a l lumberjack, and John H e n r y , the rai lroad worker, moved f rom State to State along w i t h the miners who were fo l lowing the discovery of new veins of ore, the journeymen printers and carpenters who f...