The increase of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) poses a worldwide and serious health threat. Although new antibiotics, such as daptomycin and linezolid, have been developed for the treatment of infections of Gram-positive pathogens, the emergence of daptomycin-resistant and linezolid-resistant strains during therapy has now increase...

The current study was conducted to investigate the relationship between vancomycin-resistant Enterococcus faecalis (VRE) and the presence of mazEF toxin-antitoxin (TA) system, which may be useful as target for novel antimicrobial therapy concepts. The susceptibility of E. faecalis was determined by MIC, and the presence of the mazEF TA system was evaluated by PCR. Among 200 E. faecalis isolates...

The view on enterococci has over the years shifted from harmless commensals to opportunistic but important pathogens mainly causing nosocomial infections. One important part of this development is the emergence of vancomycin resistance enterococci (VRE). The term VRE includes several combinations of bacterial species and resistance genes of which the most clinically important is Enterococcus fa...

OBJECTIVE To determine the frequency of methicillin resistant Staphylococcus aureus and its antimicrobial susceptibility pattern in patients reporting to Combined Military Hospital (CMH), Pano Aqil. STUDY DESIGN A non-interventional, cross-sectional study. PLACE AND DURATION OF STUDY Pathology Laboratory, Combined Military Hospital (CMH), Pano Aqil, from December 2005 to January 2008. MET...

Methicillin-resistant Staphylococcus aureus has been a major problem in the worldwide health care centres and institutions since the last 60 years . It has been a major pathogen responsible for nosocomial infections and recently has created life-threatening situations. Penicillin resistance was seen a few years after the drug was introduced. To solve this problem another drug of the penicillin ...

Methicillin-resistant Staphylococcus aureus (MRSA) causing nosocomial infection posed a serious therapeutic challenge. We report the prevalence, antibiotic susceptibility pattern and MIC value of vancomycin of MRSA isolates from Doon valley hospitals, Uttarakhand. Clinical specimens were collected from different hospitals were subjected to MRSA screening using conventional microbiological metho...

Methicillin-resistant Staphylococcus aureus (MRSA) with reduced vancomycin susceptibility vancomycin-intermediate S. aureus (VISA) has been reported from many countries. Whether resistance is evolving regularly in different genetic backgrounds or in a single clone with a genetic predisposition, as early results suggest, is unclear. We have studied 101 MRSA with reduced vancomycin susceptibility...

resistance of streptococcus pneumoniae against penicillin is considered to be of great importance. while low-resistant strains could be treated by penicillin, treatment of highly resistant strains is very difficult and needs broad-spectrum antibiotics. this study was performed in imam khomeini medical center, tehran, iran, from 1999 to 2001 to evaluate pneumococcal resistance against penicillin...

For 3 decades, vancomycin has been a favored therapy for serious penicillinand cephalosporin-resistant Gram-positive bacterial infections. Development of vancomycin resistance may have been restrained by the requirement for intravenous administration, which limited its use and lessened exposure to the gastrointestinal flora. Nevertheless, physicians are increasingly encountering children and ad...