Melbourne Sexual Health Centre, Alfred Hospital and School of Population Health, University of Melbourne, Melbourne, Vic. 2053, Australia. National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2010, Australia. National Centre in HIV Social Research, University of New South Wales, Sydney, NSW 2052, Australia. Australian Research Centre in Sex, Heal...

1 Systematic screening identifies dual PI3K and mTOR inhibition as a conserved 2 therapeutic vulnerability in osteosarcoma 3 4 Ankita Gupte, Emma K Baker, Soo-San Wan, Elizabeth Stewart, Amos Loh, Anang 5 A. Shelat, Cathryn M. Gould, Alistair M Chalk, Scott Taylor, Kurt Lackovic, Åsa 6 Karlström, Anthony J Mutsaers, Jayesh Desai, Piyush B Madhamshettiwar, Andrew CW 7 Zannettino, Chris Burns, Da...

The lack of observed streamflow datasets for calibration rainfall-runoff models imposes substantial problems their applicability, especially in poorly gauged or ungauged river basins. Developing satellite technologies and increasing computational powers over the past decades, have provided an environment researchers to simulate several water balance components globally using these assimilation ...

BACKGROUND Neurite orientation dispersion and density imaging (NODDI) is a diffusion magnetic resonance imaging (MRI) technique with the potential to visualize the microstructure of the brain. Revolutionary histological methods to render the mouse brain transparent have recently been developed, but verification of NODDI by these methods has not been reported. PURPOSE To confirm the concordanc...

Heart valve disease is a serious and growing public health problem for which prosthetic replacement is most commonly indicated. Current prosthetic devices are inadequate for younger adults and growing children. Tissue engineered living aortic valve conduits have potential for remodeling, regeneration, and growth, but fabricating natural anatomical complexity with cellular heterogeneity remain c...

Royal Children’s Hospital, Parkville, VIC. Katherine Thomson, MB BS, Medical Registrar, Department of Paediatrics; Margaret R Zacharin, MB BS, FRACP, Paediatric Endocrinologist, Department of Endocrinology and Diabetes. Department of Paediatrics, University of Melbourne, and Royal Children’s Hospital, Parkville, VIC. Ruth Morley, BA, MB BChir, FRCPCH, Senior Research Fellow. Maternity Services,...

OBJECTIVE Calcific aortic valve disease is associated with the differentiation of valvular interstitial cells (VICs) to myofibroblast and osteoblast-like cells, particularly in the fibrosa layer of the valve. Previous studies suggested that C-type natriuretic peptide (CNP) protects against calcific aortic valve disease to maintain homeostasis. We aimed to determine whether CNP inhibits VIC path...