A recent survey of the effects of various physical and chemical parameters on yolk protein incorporation by isolated Xenopus oocytes indicates that the Vinca alkaloid vinblastine sulfate (VLB) is among the more effective inhibitors of this process (27) . The Vinca alkaloids have received considerable attention because of their ability to disrupt the integrity of microtubules (1, 2, 21) ; theref...

toxicity usually involves marrow suppression, with neurop athy a relatively infrequent occurrence (16). VDS, a new Vinca alkaloid undergoing clinical trials, may cause both a neuropathy and marrow suppression (13). The factors un denying these clinical differences have not been clarified. In light of the differing clinical effects of these 3 drugs on the peripheral nervous system, we have exami...

The human squamous carcinoma-reactive murine monoclonal antibody PF1/D was used to derive a conjugate with the Vinca derivative 4-desacetylvinblastine-3-carboxyhydrazide (PF1/D-DAVLBHYD). This immunoconjugate was shown to be largely aggregate free and there was no loss of immunoreactivity postconjugation. When tested in vivo in a 3-day-established human squamous carcinoma nude mouse xenograft m...

Discussion: Extended Theorems in Dynamics: PROFESSOR EDWARD KASNER and DON MITTLEMAN. A Study of Lampbrush Chromosomes by the Electron Microscope: PROFESSOR G. L. CLARK, M. R. BARNES and E. R. BAYLOR. Consideration of the Adequacy of Biomicroscopy as a Method of Detecting Mild Cases of Vitamin A Deficiency: ELIZABETH C. CALLSON. Some Factors in the Nutritional Determination of History: FREDERIC...

Surface water and groundwater is contaminated with pseudoperistent xenobiotics present in the environment. The risk associated with an increase in the consumption of drugs and their permanent occurrence especially in the aquatic environment falls on non-target organisms. The aim of this thesis was to assess the effect of increasing concentrations of paracetamol (0.1; 10; 100 μg/l) on the growth...

For an integer l ≥ 2, let U(l) be the class of matroids with no U2,l+2-minor. A matroid in U(l) is extremal if it is simple and has no simple rank-preserving singleelement extension in U(l). An amalgam of two matroids is a simultaneous extension of both on the union of the two ground sets. We study amalgams of extremal matroids in U(l): we determine which amalgams are in U(l) and which are extr...

In continuation of previous research, the anticancer screening formulation herbal syrup Vinca extract was performed. The performed as per reported literature method. cancer on two Human cell lines. These lines were Lung Cancer line A549 and Breast Cell MCF7. found to be devoid properties.

Vincaleukoblastine (VLB) is a compound recently isolated from Vinca rosea L i n n . Chemical studies by Gorman et al. (6) indicated that it belongs to a new class of dimeric alkaloids containing both indole and dihydroindole moieties. VLB possesses a marked leukopenic effect, due to depression of leukopoiesis (4, 10). I t has been found that this alkaloid is active against several animal tumors...

A multidrug-resistant variant of the human HL-60 promyelocytic leukemia cell line (HL-60/MX2) has been isolated in vitro by subcultiiring these cells in progressively increasing concentrations of mitovaut rone. The MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinontycin, 4'-(9-acridinylamino)methanesulfon-m-anisididc, and the anthracyclines daunorubicin and doxorubicin...