نتایج جستجو برای: viral vector

تعداد نتایج: 341208  

Journal: :Journal of Microbiology and Biotechnology 2020

2012
Arnaud Zaldumbide Françoise Carlotti Manuel A. Gonçalves Shoshan Knaän-Shanzer Steve J. Cramer Bart O. Roep Emmanuel J. H. J. Wiertz Rob C. Hoeben

Viral gene carriers are being widely used as gene transfer systems in (trans)differentiation and reprogramming strategies. Forced expression of key regulators of pancreatic differentiation in stem cells, liver cells, pancreatic duct cells, or cells from the exocrine pancreas, can lead to the initiation of endocrine pancreatic differentiation. While several viral vector systems have been employe...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
H H Chen L M Mack R Kelly M Ontell S Kochanek P R Clemens

Genetic correction of inherited muscle diseases, such as Duchenne muscular dystrophy, will require long term expression of the recombinant protein following gene transfer. We have shown previously that a new adenoviral vector that lacks all viral genes expressed both full-length dystrophin and beta-galactosidase in mdx (dystrophin-deficient) mouse muscle. We observed a significant histologic im...

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