An experiment was developed using aeration of water for demonstrating the phenomenon of mass transfer. The demonstration was designed to provide both conceptual and practical insight of the mass transfer process. A bubble column fitted with a sieve tray was used to carry out the experiment. The air flow rate and hole size of the sieve tray were varied. Mass transfer coefficient was obtained fro...

Chromatographic data pertaining to the enantioseparation of L- and D-phenylalanine anilide (PA) on a polymeric stationary phase imprinted with L-PA were studied from the viewpoints of phase equilibrium, mass transfer kinetics, and the thermodynamic properties of this enantiomeric separation system. The concentration dependence of the lumped mass transfer rate coefficient (k(m,L)) previously pub...

The dissolved gas concentration in a stirred tank has significant importance the chemical and biological processing industries as mass transfer from injected to an aqueous solution must occur for be usable. As solubility of is low there are no probes measuring concentration, volumetric coefficient selected criterion design scale-up reactors. However, it difficult accurately predict non-equilibr...

Accurate knowledge of volumetric oxygen mass transfer coefficients in multiphase systems is important for successfully designing and efficient operation process plants. As a result, large number papers on the determination kLa have been published literature. The dynamic degassing method probably most common determining coefficient. However, little work known influence countercurrent diffusion e...

BACKGROUND Upstream bioprocesses are extremely complex since living organisms are used to generate active pharmaceutical ingredients (APIs). Cells in culture behave uniquely in response to their environment, thus culture conditions must be precisely defined and controlled in order for productivity and product quality to be reproducible. Thus, development culturing platforms are needed where man...

The gas–liquid hydrodynamics and mass transfer were studied in a concentric tube internal jet-loop airlift reactor with conical bottom. Comparing standard design, the gas separator was equipped an adjustable deflector placed above riser. effect of riser superficial velocity uSGR on total holdup ?GT, homogenization time tH, overall volumetric liquid-phase coefficient kLa investigated laboratory ...

Oxygen supply and dissolved carbon dioxide (dCO(2)) stripping are two of the most important control parameters in cell culture. In this study, we investigated the effect of scale-up on the volumetric gas transfer coefficient with bioreactors of different sizes (working volume: 80 L, 500 L, 2000 L, and 10,000 L; aspect ratio: 1.0-1.6). Sparging air into water increased the volumetric oxygen tran...

A novel adsorption differential volumetric apparatus was developed for the determination of diffusional time constants in nanoporous materials and applied to diffusion nitrogen argon commercial pellets 4A zeolite. The system is designed high rates data acquisition allowing determine mass transfer seconds over pressure range from vacuum 130 kPa. Diffusion N2 Ar on a single pellet fragments obtai...

Introduction Much has been written and said about the scale-up of fermentation systemsS). In general, it has been agreed that the best scale・,-up method is to maintain a constant voiumetric oxygen mass transfer coeMcient. The problem with this procedure has been the differing methods by which the transfer coeMelent has been obtained. Various investigators have used the su}fite oxidation2), pola...