A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of V...

OBJECTIVE The advances achieved in the surgical management of vulvar squamous cell carcinoma (SCC) have not been mirrored in systemic therapy options. The objective of this paper is to summarize current evidence regarding systemic therapy in vulvar cancer, review the latest research on the biology of this disease, and identify future strategies to improve patient management. METHODS MEDLINE a...

Histologically, vulvar intraepithelial neoplasm (VIN) is a proliferative disorder of the female vulva. No single clinical characteristic or pathognomonic feature facilitates the diagnosis of VIN, and the agreement between different pathologists on the diagnoses varies significantly. In this study, we evaluate the immunohistochemical expression patterns of E-cadherin and β-catenin in 22 patients...

PTEN, a candidate tumor suppressor gene located at chromosome 10q23.3, has been shown to be mutated in approximately 40% of endometrial cancers. Such mutations have also been identified in endometrial hyperplasia, indicating that inactivation of the PTEN tumor suppressor gene is an early event in the genesis of some endometrial cancers. In this study, we have extended the analysis of PTEN in gy...

Vulvar carcinoma is rare, accounting for less than 5% of all vulvar neoplasms and less than 1% of all neoplasms. Vulvar SCCs are usually diagnosed late because they are often asymptomatic and tend to grow at slow rates. They may be invasive and destructive if neglected or improperly treated. Nevertheless, they have a very low propensity for metastatic spread, but frequently recur after simple e...

OBJECTIVES The purpose of this study is to statistically compare the mean ages of the patients with gynecologic cancer in our hospital during the 2000-2009 interval. MATERIAL AND METHODS The data was collected from the Histopathology Exams (HPE) registers. RESULTS Gynecologic cancer was discovered in 1244 cases: 731 cervical cancers, 392 uterine cancers, 82 ovarian cancers, 31 vulvar cancer...

Dear Editor, We report a patient with metastatic Crohn’s disease (MCD) who presented with vulvar swelling preceding the diagnosis of gastrointestinal disease. Vulvar involvement of Crohn’s disease (CD) is rare and difficult to diagnose, especially when it precedes the onset of overt gastrointestinal symptoms. In our case, the diagnosis was enigmatic because no radiological and laboratory examin...

Background Vulvar carcinomas comprise almost 5% of all malignant tumors of the female genital tract [1]. Primary therapeutic approach is considered a radical surgery [2]. Infection and wound breakdown are the most common complications, these occur in approximately 40-60% of patients [3]. Objective to value the efficacy of platelet gel as support for reconstructive surgery in recurrent vulvar ca...

BACKGROUND Vulvar cancer is a relatively rare malignancy, which occurs most often in postmenopausal women. We have previously identified a geographic cluster of vulvar cancer in young Indigenous women living in remote communities in the Arnhem Land region of Australia. In this population, we investigated the prevalence of oncogenic human papillomavirus (HPV) infection in anogenital samples (vul...