Since the cloning of the cystic fibrosis transmembrane regulator (CFTR) protein in the late 1980s and subsequent significant advances in understanding the pathophysiology of cystic fibrosis (CF) there have been high expectations that transformative, disease-modifying therapies could be developed. 2 Dysfunction of the CFTR protein results in significant reduction or absence of chloride transport...

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In this work we study the global approximate multiplicative controllability for the linear degenerate parabolic Cauchy-Neumann problem  vt − (a(x)vx)x = α(t, x)v in QT = (0, T )× (−1, 1) a(x)vx(t, x)|x=±1 = 0 t ∈ (0, T ) v(0, x) = v0(x) x ∈ (−1, 1) , with the bilinear control α(t, x) ∈ L(QT ). The problem is strongly degenerate in the sense that a ∈ C([−1, 1]), positive on (−1, 1), is all...

We prove existence of a solution u for the nonlinear elliptic system -div a(x,u,Du) =/ i in V(Q,), u = 0 on dfl where \x is Radon measure on Q with finite mass. In particular we show that if the coercivity rate of a lies in the range (1,2 — ^] then u is approximately differentiable and the equation holds with Du replaced by ap Du. The proof relies on an approximation of // by smooth functions f...

We report here our preliminary results on the use of catalytic antibodies as an approach to neutralizing organophosphorus chemical weapons. A first-generation hapten, methyl-alpha-hydroxyphosphinate Ha, was designed to mimic the approach of an incoming water molecule for the hydrolysis of exceedingly toxic methylphosphonothioate VX (1a). A moderate protective activity was first observed on poly...

This study investigated the possibility of an alternative to chemical medication in the treatment of sexual dysfunction in healthy women. The efficacy of a unique herbal formulation of Muira puama and Ginkgo biloba (Herbal vX) was assessed in 202 healthy women complaining of low sex drive. Various aspects of their sex life were rated before and after 1 month of treatment. Responses to self-asse...