In impulse response analysis estimation uncertainty is typically displayed by constructing bands around estimated impulse response functions. These bands may be based on frequentist or Bayesian methods. If they are based on the joint distribution in the Bayesian framework or the joint asymptotic distribution possibly constructed with bootstrap methods in the frequentist framework often individu...

5.1. The problem 5.2. The test statistics 5.3. The inequality 5.4. A numerical example 5.5. Instrumental variables 6. Asymptotic equivalence and optimality of the test statistics 7. The Lagrange Multiplier test as a diagnostic 8. Lagrange Multiplier tests for non-spherical disturbances 8.1. Testing for heteroscedasticity 8.2. Serial correlation 9. Testing the specification of the mean in severa...

Despite the successful discovery of hundreds of variants for complex human traits using genomewide association studies, the degree to which genes jointly affect disease risk is largely unknown. One obstacle toward this goal is that the computational effort required for testing gene-gene interactions is enormous. As a result, numerous computationally efficient tests were recently proposed, such ...

PHENOTYPE PREDICTION AND FEATURE SELECTION IN GENOME-WIDE ASSOCIATION STUDIES by Andrew Roberts Genome wide association studies (GWAS) search for correlations between single nucleotide polymorphisms (SNPs) in a subject genome and an observed phenotype. GWAS can be used to generate models for predicting phenotype based on genotype, as well as aiding in identification of specific genes affecting ...

Common mental health consequences following the experience of potentially traumatic events include Posttraumatic Stress Disorder (PTSD) and addictive behaviors. Problematic smartphone use is a newer manifestation of addictive behaviors. People with anxiety severity (such as PTSD) may be at risk for problematic smartphone use as a means of coping with their symptoms. Unique to our knowledge, we ...

material is a single molecular species, rather than a mixture of the native and slightly modified pignments. Note added in pro9f: Since this account was written we have observed regenerations of 85 per cent in purified cattle rhodopsin, flooded with retinenel, and bleached for 1 minute in intense light. 11 Wald, G., Documenta Ophthal., 3, 94 (1949). 12 Shantz, E. M., Embree, N. D., Hodge, H. C....

BACKGROUND The association between lesion type, disease stage and severity of pain was studied in a large group of women with endometriosis to verify whether endometrial implants at different sites determine specific complaints and to evaluate the validity of the current classification system in women with symptomatic disease. METHODS A total of 1054 consecutive women with endometriosis under...

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable psychiatric disorders. While previous studies have focussed on mapping focal or connectivity differences at the group level, the present study employed pattern recognition to quantify group separation between unaffected siblings, participants with ADHD, and healthy controls on the basis of spatially distr...

In this paper we introduce three natural “score statistics” for testing the hypothesis that F (t0) takes on a fixed value in the context of nonparametric inference with current status data. These three new test statistics have natural intepretations in terms of certain (weighted) L2 distances, and are also connected to natural “one-sided” scores. We compare these new test statistics with an ana...