Wake-sleep (W-S) states are affected by thermoregulation. In particular, REM sleep (REMS) is reduced in homeotherms under a thermal load, due to an impairment of hypothalamic regulation of body temperature. The aim of this work was to assess whether osmoregulation, which is regulated at a hypothalamic level, but, unlike thermoregulation, is maintained across the different W-S states, could infl...

Obesity-induced lipid oversupply promotes skeletal muscle mitochondrial biogenesis. Previous investigations have utilized extreme high-fat diets (HFD) to induce such mitochondrial perturbations despite their disparity from human obesogenic diets. Here, we evaluate the effects of Western diet (WD)-induced obesity on skeletal muscle mitochondrial function. Long-Evans rats were given ad libitum ac...

background: wilson disease (wd) is caused by numerous pathogenic mutations of the atp7b gene. there are several mutation screening methods that can be used for the diagnosis and carrier detection of wd, however such methods are costly and time-consuming. therefore, other diagnostic methods should be used for urgent situations such as prenatal diagnosis. objective: to report common polymorphisms...

Withdrawal anxiety is a significant factor contributing to continued alcohol abuse in alcoholics. This anxiety is long-lasting, can manifest well after the overt physical symptoms of withdrawal, and is frequently associated with relapse in recovering alcoholics. The neurobiological mechanisms governing these withdrawal-associated increases in anxiety are currently unknown. The basolateral amygd...

In recent years several Dwarf Novae (DN) systems have been observed in quiescence, when the accretion rate is low and the WD photosphere can be directly detected. The WDs are observed to cool after the DN outburst from high effective temperatures to lower effective temperatures (Teff) thought to be indicative of the thermal state of the deep interior of the WD. Sion has argued that the most lik...

Leaf conductance, water relations, growth, and abscisic acid (ABA) concentrations in xylem sap, root apices and leaves were assessed in oak seedlings (Quercus robur L.) grown with a root system divided between two compartments and subjected to one of four treatments: (a) well watered, WW; (b) half of root system exposed to soil drying and half kept well watered, WD; (c) whole root system expose...

Mutations in the brain-derived neurotrophic factor (BDNF) gene are associated with human obesity, and BDNF has potent inhibitory effects on eating and body weight. Little is known about the effects of energy balance manipulations on BDNF protein in the hypothalamus, though this brain region is critical for regulation of feeding and body weight and has high levels of BDNF. Here we investigated t...

BACKGROUND Whipple's disease (WD) is an infectious disease caused by Tropheryma whipplei, which replicates in macrophages and induces the release of interleukin (IL)-16, a substrate of caspase 3, and macrophage apoptosis. The disease is characterized by intestinal, cardiac or neurological manifestations; its diagnosis is based on invasive analysis requiring tissue biopsies or cerebrospinal flui...

The aim of this study was to investigate aerobic exercise training as a means to prevent erectile dysfunction (ED) and coronary artery disease (CAD) development associated with inactivity and diet-induced obesity. Male Sprague-Dawley rats were fed a Western diet (WD) or a control diet (CD) for 12 wk. Subgroups within each diet remained sedentary (Sed) or participated in aerobic interval treadmi...

The Wigner distribution (WD) possesses a number of desirable mathematical properties relevant time-frequency analysis. However, the presence of interference terms renders the WD of multicomponent signals extremely di cult to interpret. In this work, we propose an adaptivedecomposition of the WD using extended libraries of orthonormal bases. A prescribed signal is expanded on a basis of adapted ...