CONTEXT The subjectivity of pain causes enormous difficulties in evaluating neonatal pain with a single, practical and easy-to-apply tool. Pain evaluation in the neonatal period should be performed by valid, safe, useful and feasible methods. OBJECTIVE To evaluate the validity of the Neonatal Facial Coding System (NFCS), Neonatal Infant Pain Scale (NIPS), heart rate (HR) and O2 saturation (O2...

BACKGROUND Obesity is related to underestimation of one's own weight. AIM To determine the agreement between nutritional status and self perception of weight status in apparently healthy adults from Talca. SUBJECTS AND METHODS Data were obtained from a survey applied at 1007 randomly selected subjects, aged 18-74 years old (66% women). The survey identified age, gender, educational level an...

BACKGROUND Arterial level repair is considered the most appropriate procedure for transposition of the great arteries. This report describes our experience with the arterial switch operation over the past decade. METHODS AND RESULTS From January 1991 to January 2001, a total of 299 patients underwent an arterial switch operation for transposition of the great arteries or double-outlet right v...

Fosmidomycin is effective against malaria, but it needs to be given for > or =4 days when used alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and efficacy of consecutively shortened regimens of artesunate-fosmidomycin (1 to 2 mg/kg of body weight and 30 mg/kg of body weight, respectively; doses given every 12 hours). All dosing regimens were...

BackgroundRecombinant human C1 esterase inhibitor (rhC1-INH) is indicated in the United States for treatment of acute hereditary angioedema (HAE) attacks adolescents and adults; it also Europe children aged 2 years older. A need exists further insight into potential pharmacokinetic (PK) differences functional C1-INH levels by age (ie, children, adolescents, adults).ObjectiveTo perform populatio...

Reproductive performance is steadily increasing within the pork industry; logically, amino acid requirements need to be redefined for sows producing larger litters. The objective of this study was to determine the threonine requirement of the high-producing lactating sow and to determine the effect of lysine on this requirement. A total of 419 PIC C-15 sows were assigned randomly to treatment w...

BACKGROUND Iatrogenic hypothyroidism is associated with an increased incidence of azotemia after treatment of hyperthyroidism, and decreased survival time in azotemic hyperthyroid cats. HYPOTHESIS Restoration of euthyroidism will decrease plasma creatinine concentrations. ANIMALS Nineteen client-owned, methimazole- or carbimazole-treated, hyperthyroid cats with documented iatrogenic hypothy...

Objective The objective of this study was to determine the maternal and fetal pharmacokinetic (PK) profiles of acetaminophen after administration of a therapeutic oral dose. Study Design After obtaining Institutional Review Board approval and their written informed consent, pregnant women were given a single oral dose (1,000 mg) of acetaminophen upon admission for scheduled cesarean delivery. M...