Identification of Pygopus in Drosophila as a dedicated component of the Wg (fly homolog of mammalian Wnt) signaling cascade initiated many inquiries into the mechanism of its function. Surprisingly, the nearly exclusive role for Pygopus in Wg signal transduction in flies is not seen in mice, where Pygopus appears to have both Wnt-related and Wnt-independent functions. This review addresses the ...

Most of this article concerns the uses of LARS and the two related methods in the age-old, " somewhat notorious, " problem of " [a]utomatic model-building algorithms.. . " for linear regression. In the following, I will confine my comments to this notorious problem and to the use of LARS and its relatives to solve it. 1. The implicit assumption. Suppose the response is y, and we collect the m p...

The mechanisms by which the Wingless (Wg) morphogen modulates the activity of the transcriptional activator Armadillo (Arm) to elicit precise, concentration-dependent cellular responses remain uncertain. Arm is targeted for proteolysis by the Axin/Adenomatous polyposis coli (Apc1 and Apc2)/Zeste-white 3 destruction complex, and Wg-dependent inactivation of destruction complex activity is crucia...

Rangelands are one of the most vulnerable parts concerning the climatechanges‟ impacts. These impacts are even stronger in the arid and semi-arid areas whererangeland ecosystems are in critical conditions. Therefore, it is crucial to figure out theactual dynamics of climate variations on the rangelands. The aim of this research was todetermine climate changes in Khabr rangeland, Kerman, Iran. S...

in agricultural meteorology, the growing season is the period within each year when crops can be grown from a view of thermal conditions. this period is in general, between the last and first frost dates in spring and autumn when temperature is above a specific threshold. there are two other definitions when using a 5 °c as threshold. one of the methods employed in studying future climate is us...

today, there arevarious statistical models for the discrete simulation of the rainfall occurrence/non-occurrence with more emphasizing on long-term climatic statistics. nevertheless, the accuracy of such models or predictions should be improved in short timescale. in the present paper, it is assumed that the rainfall occurrence/non-occurrence sequences follow a two-layer hidden markov model (hm...

assessing the potential impacts of 21st-century climate change on species distributions and ecological processes requires climate scenarios with sufficient spatial resolution. in this study we projected future changes in maximum temperature and minimum temperature under cmip3 sres and cmip5 rcps scenarios with two station-based datasets (arazkoseh and nodeh) of the eastern golestan province. ch...