A diffusion model of tumor growth, vascularization and necrosis is used to analyze experimental data describing the temporal changes in tumor cell and blood vessel radial distributions in a host-tissue field transplanted with a fibrosarcoma. The dynamic changes can be explained by a mathematical model which views the process as one of diffusion and proliferation in time and space. Coupled diffu...

The Origins of Cancer Symposium is a meeting organized by graduate students at the Van Andel Research Institute and serves as a forum for focused discussion on factors that contribute to the etiology of cancer. The theme for the fifth annual Origins of Cancer held on July 11th, 2014 was Beyond the Tumor Cell, which focused on the complex influences coming from the environment in which the cance...

We report the draft genome sequence of Streptomyces sp. TP-A0648 isolated from a leaf of Aucuba japonica This strain produces a new tumor cell growth inhibitor designated anicemycin. The genome harbors at least 12 biosynthetic gene clusters for polyketides and nonribosomal peptides, suggesting the potential to produce diverse secondary metabolites.

Targeted radiotherapy has the potential to provide radiation doses from a wide range of radionuclides, some of them suitable for killing single cells while others are more suitable for killing tumor cell clusters of various sizes. A list of 64 radionuclides, including 20 new potential candidates for therapy (73Ga, 75Se, 87mSr, 97Ru, 103Ru, 113Sn, 113mIn, 117Sb, 123Sn, 131Cs, 139Ce, 141Ce, 149Eu...

Intraneoplastic diversity in human tumors is a widespread phenomenon of critical importance for tumor progression and the response to therapeutic intervention. Insights into the evolutionary events that control tumor heterogeneity would be a major breakthrough in our comprehension of cancer development and could lead to more effective prevention methods and therapies. In this paper, we design a...