INTRODUCTION Mucopolysaccharidoses (MPS) are a group of inherited disorders due to lysosomal enzyme deficiencies. The aims of this study are to describe the neuroimaging findings in children evaluated in our hospital with this diagnosis, looking for a possible correlation of these alterations with the type of MPS and clinical severity, and finally to compare these findings with those previously...

BACKGROUND Catheter ablation is increasingly used for rhythm control in symptomatic atrial fibrillation (AF), but the demographic characteristics of patients undergoing this procedure are unclear. METHODS AND RESULTS We used data on all admissions at nonfederal acute care hospitals in California, Florida, and New York to identify patients discharged with a primary diagnosis of AF between 2006...

Introduction Ventricular fibrillation (VF) triggered by premature ventricular contraction (PVC) most frequently originates from the His-Purkinje system and right ventricular outflow tract (RVOT) in patients with idiopathic VF. Radiofrequency catheter ablation (RFCA) of triggering PVCs is reportedly useful for the successful elimination of VF. The diagnosis of early repolarization (ER) syndrome ...

Atrial fibrillation (AF) is the most common sustained arrhythmia and its treatment continues to be a challenge. Recently, delayed enhancement (DE)-MRI was introduced in the diagnosis and treatment of AF by the assessment of atrial fibrosis, which is considered the hallmark of the arrhythmogenic substrate in AF. Atrial fibrosis was reported to be an independent predictor of arrhythmia recurrence...

Background Epidemiological data indicate that 0.1% to 0.3% of the general population have ECG findings suggesting that during sinus rhythm, in addition to AV conduction over the AV node His pathway, there is also AV conduction over an accessory AV pathway (AP).4 This means that each year 4 new cases are found in a population of 100 000. It is also known that there is a 4-fold increase of this f...

recurrent paroxysmal tachycardia was admitted to hospital because of chest pain. The electrocardiogram (ECG) on admission (Figure 1A) showed signs suggestive of an antero septal accessory pathway, as well as ST segment elevation in leads V1 through V4, aVL and aVR, with elevated levels of cardiac enzymes. This was consistent with a diagnosis of Wolff–Parkinson–White syndrome with acute myocardi...

Radio frequency (RF) catheter ablation of accessory pathways represents an interventional method in modern cardiology that has become the first-line treatment for patients with symptomatic WPW-syndrome. The aim of this study was to analyze: (1) the learning curve for the ablation procedure; (2) procedural parameters and success; and (3) personal assessment of the treatment by the patients. Lear...

The aim of this survey was to provide insight into current practice regarding the management of paediatric arrhythmias in Europe. The survey was based on a questionnaire sent via the Internet to the European Heart Rhythm Association (EHRA) electrophysiology research network centres. The following topics were explored: patient and treatment selection, techniques and equipment, treatment outcomes...

Fragile X syndrome, the most common form of hereditary mental retardation, causes disruption in the development of dendrites and synapses, the targets for axonal growth in the central nervous system. This disruption could potentially affect the development, wiring, and targeting of axons. The current study utilized diffusion tensor imaging (DTI) to investigate whether white matter tract integri...