We have previously suggested that the decrease in the levels of serum total thyroxine (T(4)) and free T(4) by a single administration to rats of Kanechlor-500 (KC500) at a dose of 100 mg/kg is not necessarily dependent on the increase in hepatic T(4)-UDP-glucuronosyltransferase (UDP-GT). In the present study, we determined whether or not a consecutive treatment with KC500 at a relatively low do...

This study was designed to evaluate the effect of drag reducer polymers (DRP) on arteries from normotensive (Wistar) and spontaneously hypertensive rats (SHR). Polyethylene glycol (PEG 4000 at 5000 ppm) was perfused in the tail arterial bed with (E+) and without endothelium (E-) from male, adult Wistar (N = 14) and SHR (N = 13) animals under basal conditions (constant flow at 2.5 mL/min). In th...

BioBreeding (BB) rats are derived from an outbred colony of Wistar rats and are used as a model of autoimmune diabetes mellitus. A corticosteroid binding globulin (CBG) variant with reduced affinity for glucocorticoids has now been found in the blood of these animals. The dissociation rate constants of BB CBG for cortisol (4.42 nM) and corticosterone (1.43 nM) are both about 50% higher than tho...

various stresses during life can affect metabolism and brain activities, immune and endocrine systems directly and indirectly, and ultimately, causes animal behavior change. the cellular and molecular level change in neurotransmitter and hormone concentrations led to the functional changes of operating systems in the intracellular organelles.  these events cause of course oxidative stress. all ...

Ekstrak kulit manggis (Garcinia mangostana L.) mengandung xanthone dengan senyawa utama alfa mangostin dan gamma-mangostin yang berfungsi sebagai antioksidan dalam melindungi mukosa lambung. Tujuan dari penelitian ini ingin mengetahui pengaruh pemberian ekstrak pelindung lambung tikus diinduksi asam asetilsalisilat (ASA). Penelitian menggunakan 24 ekor dibagi menjadi empat kelompok perlakuan te...

Diclofenac sodium (DF) is a non-steroidal anti-inflammatory drug (NSAID) that possesses antipyretic, analgesic, antinociceptive and activities. Like other NSAIDs, DF known to be associated with renal, cardiovascular, gastrointestinal complications. The present study was carried out evaluate the adverse effects of in vivo wistar albino rats assess if oral administration organic osmolyte betaine ...

ligature-induced alveolar bone loss and TNF-α secretion in Wistar rats. Thirty-three male Wistar rats aged 45-60 days (mean weight=253 g) were randomly allocated test or control groups. Test group (n=18) received 15% alcohol as liquid intake and control group (n=15) received water during the experimental period. TNF-α was analyzed by ELISA assay in 11 animals per group. After 14 days of alcohol...

The spontaneously hypertensive rat (SHR) initially bred in Kyoto is the most widely studied animal model of essential hypertension. As controls for the SHR, most workers have used normotensive descendants of Wistar rats from the colony in Kyoto from which the SHR strain was derived (Wistar-Kyoto rats, WKY). But the presumption that WKY are serviceable controls for SHR rests on the tacit assumpt...

Thyroid dysplasia was recognized in WistarHan GALAS rats and confirmed as a heritable congenital disorder. The gene or genes involved were not identified, but homozygous animals with thyroid dysplasia also exhibited stunted growth, had reduced pituitary gland growth hormone (GH) and were hypothyroid. Heterozygous animals exhibited thyroid dysplasia with normal thyroid hormonal homeostasis and n...