OBJECTIVES Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting the synovial joints of the body. Methotrexate (MTX) is considered as a mainstay in the management of RA. However, monotherapy with MTX in RA is often limited by potential long-term toxicity. The present study was conducted to evaluate if MTX-pioglitazone combination therapy has an add-on benefit over mono...

Ethanol consumption affects maternal nutrition, the mothers' antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three group...

Acrylamide (AC) is a noxious chemical and it is widely used in this modernized world. There by this study aimedto assess the acrylamide induced neurotoxicity and genotoxicityonmale wistar rat brain. Based on the study aim, male at brainwas exposed by short term and long term to acrylamide and investigated the crucial changes in glutathione S-transferases and its associated glutathione peroxidas...

A fused triplet placenta was observed in a Wistar Hannover rat on gestation day 15. Each (referred to as PL-A, PL-B, and PL-C) of this attached one fetus each, but their fetal weights were lower than that the only normal PL-N) dam. Histopathologically, thinning trophoblastic septa dilatation maternal sinusoid labyrinth zone PL-B PL-C, not PL-A or PL-N. The points placental fusion at junctional ...

Eksojen antioksidan takviyesinin, diyabetin mikro ve makrovasküler komplikasyonlarına karşı faydalı olabileceği bilinmektedir. Bu çalışmada C vitamini desteğinin, diyabetik ratlarda, kronik hiperglisemiye bağlı olarak bozulan insülin sekresyonu, hiperlipidemi, oksidatif stres paraoksonaz-1 enzim (PON1) aktivitesi üzerine etkilerinin araştırılması amaçlanmıştır. amaçla, yirmi dört adet Wistar al...

Between 9 and 46% of those being treated for major depressive disorder had a partial or no response to antidepressants. Research is needed produce more effective safer antidepressant. Terminalia chebula stimulates the CNS. The goal this research determine whether chronic administration aqueous extract fruit pulp dosages (100, 200, 400 mg/kg) have antidepressant effects. behavioural model rats w...

For scores of years now, several microfinance organizations, non governmental organizations and other welfare organizations have, with a view to aiding the progress of communities rooted in poverty have been focusing on creating microentrepreneurs, besides taking several other measures. In recent times, business corporations have joined forces to combat poverty by taking up microenterprise deve...

The objective of the study was to determine the anticancerous efficacy of Ayurvedic preparation made of Semecarpus anacardium (SA) nuts. Five groups of rats were used for the study. Group I served as water control. Hepatocellular carcinoma (HCC) was induced in groups II, III and IV animals using N-nitrosodiethylamine as inducing agent followed by phenobarbitone as promoter for 13 weeks. Group-I...

BACKGROUND It is well known that exercise training has positive effect on catecholamine response to a given work load. But in this regard, the effective method of training needs to be studied. OBJECTIVES The aim of this study was to compare the effects of 8 weeks endurance exercise with two overloading patterns on the left ventricular catecholamine levels. MATERIALS AND METHODS 29 male Wist...

BACKGROUND Grewia carpinifolia is a plant commonly used in the tropics to manage various central nervous system (CNS) disorders. However, despite its widespread use no scientific work has been reported to validate these claims. OBJECTIVES To evaluate the activity of G. carpinifolia as it affects behaviour using animal model. METHODS Twenty five adult Wistar rats were randomly divided into f...