OBJECTIVE To delineate age-dependent and tissue-specific molecular activities of the variant-inclusion fibronectin transcripts in fetal and postnatal skin and airway mucosal wounds during early events of the wound healing process. Fibronectin is involved in multiple steps of the wound healing process. The functional complexity of fibronectin is carried through its protein diversity, which is co...

OBJECTIVE In forensic medicine it is important to determine the age of skin wounds in living subjects. The aim of this study was to assess whether analysis of inflammatory cells and inflammatory mediators in skin biopsies of wounds from living subjects could improve wound age determination. METHODS Biopsies (n=101), representing the superficial border area of a skin wound, were taken from ski...

UNLABELLED  Collagen synthesis and degradation are important in scar maturation. Collagenase has been used for debridement of wounds and treatment of Dupuytren's disease but its effects on scar prevention are unknown. OBJECTIVE The objective of this study was to determine the effect of collagenase ointment on hypertrophic scar prevention by using a rabbit ear-scarring model. METHODS F...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Grzela T. Cathelicidin – what’s new in the treatment of chronic wounds?. Leczenie Ran. 2021;18(2):45-50. doi:10.5114/lr.2021.107148. APA Grzela, (2021). Ran, 18(2), 45-50. https://doi.org/10.5114/lr.2021.107148 Chicago Tomasz. 2021. "Cathelicidin wounds?". Ran 18 (2): Harvard pp.45-50. MLA wounds?." vol. 18, no. 2...

The aim of the study was to investigate wound healing and scar formation in rabbit corneal lamellar wounds repaired with simple interrupted sutures (SIS) or horizontal mattress sutures (HMS). Two parallel 'I'-shaped lamellar cornea wounds were created in one eye of 40 white New Zealand rabbits, while 5 uninjured rabbits were sacrificed to serve as normal controls. One side of the wounds, in the...

Surgical wounds in cancer patients have a relatively high dehiscence rate. Although cancer resections are performed so as to include macroscopically non-involved tissues, some cancer cells can be present in the line of transection or surrounding tissues (R1 and R2 resections). The local healing process may facilitate proliferation of these localized cancer cells, and the high cytokine concentra...

OBJECTIVE Negative pressure wound therapy (NPWT) can be delivered in continuous or noncontinuous modes, while NPWT with instillation (NPWTi) couples NPWT with automated delivery and removal of topical wound treatment solutions and suspensions. This porcine study compared granulation response of NPWTi (instillation foam dressing with saline) to NPWT (standard foam dressing) in continuous and non...

Objective. Mesenchymal stem cells (MSCs) isolated from the umbilical cord and their conditioned media (CM) can be easily obtained and refined compared with stem cells from other sources. Here, we explore the possibility of the benefits of these cells in healing diabetic wounds. Methodology and Results. Delayed wound healing animal models were established by making a standard wound on the dorsum...