The f3-adrenoceptor-blocking and class II1 effects of sotalol were assessed in 1 1 patients with inducible orthodromic reciprocating tachycardia. Serum sotalol concentration, maximum exercise heart rate, and electrophysiologic study data were obtained at control, at the /3-adrenoceptor-blocking dosage (407 149 mg/day, 1.4 0.5 ,ug/m-1), and at the maximum well-tolerated dosage (924 + 337 mg/day,...

BACKGROUND Therapeutic management of asymptomatic patients with a Wolff-Parkinson-White (WPW) pattern is controversial. We compared the risk:benefit ratios between prophylactic radiofrequency ablation and no treatment in asymptomatic patients with WPW. METHODS AND RESULTS Decision analysis software was used to construct a risk-benefit decision tree. The target population consisted of 20- to 4...

The aims of this survey was to provide insight into treatment activity, the strategy of treatment, and risk stratification of patients with asymptomatic and symptomatic ventricular pre-excitation across Europe. Fifty-eight centres, members of the European Heart Rhythm Association EP research network, covering 20 countries answered the survey questions. All centres were high-volume ablation cent...

A 15-year-old female with WPW syndrome and normal heart underwent an electrophysiology study for paroxysmal palpitations and syncope. Intravenous adenosine produced an unexpected response of QRS changes and advanced AV block. During isoproteronol infusion, short-lasting and poorly tolerated wide QRS tachycardia was inducible, but pacing maneuvers were not feasible during tachycardia to determin...

cal prolonged QT syndrome is strongly promoted by excessive adrenergic influence, such as might have arisen from the patient's septic, dehydrated state.3 Intravenous adenosine possesses a significant short-lived antiadrenergic effect.6 However, in this case any potential beneficial anti adrenergic effect was overridden by adenosine-induced bradycardia. Moreover, there is ftO'indication that the...

This paper presents a new non-invasive method to estimate the danger to which are exposed the patients suffering from Wolff-Parkinson-White (WPW) syndrome. Our aim is to provide reliable risk estimation, and to formulate its limitations. The first task is the localization of the accessory pathway (AcP), which we solved using the stepwise Arruda algorithm. After getting the AcP location it was p...

CONTEXT Wolff-Parkinson-White (WPW) is a cardiac conduction system disorder characterized by abnormal accessory conduction pathways between the atria and the ventricles. Symptomatic patients classically present with palpitations, presyncope, or syncope that results from supraventricular tachycardia. While rare, sudden cardiac death may be the first manifestation of underlying disease and occurs...

To the Editors: Supraventricular tachycardia (SVT) encompasses all types of tachycardia that start from above the bifurcation of the bundle of His with a heart rate ranging from 150 to 250 beats/min in children.1,2 Paroxysmal SVT occurs suddenly and can end rapidly.1 We describe a healthy 3-year-old boy who developed primary SVT during intraoperative extraocular muscle manipulation. Our patient...

Unlike the adult population, arrhythmias occur less commonly in childhood. Only 5% of the emergency hospital admissions in the paediatric population is attributed to symptomatic arrhythmias.1 Majority of these tend to be accessory pathway mediated supraventricular tachyarrhythmias such as Wolff-Parkinson-White (WPW) syndrome, permanent junctional reciprocating tachycardia (PJRT) and Mahaim tach...

6 List of original papers 7 List of abbreviations 8 Introduction 9 Cardiac cellular electrophysiology 12 Recording cardiac electricity 16 Electrocardiography (ECG) 16 Vectorcardiography (VCG) 16 Pacemaker treatment 20 Sick Sinus Syndrome 21 Hypertrophic Obstructive Cardiomyopathy (HOCM) 21 Wolff-Parkinson-White Syndrome (WPW syndrome) 22 Aims 23 Material and Methods 24 Studies I and II 24 Study...