The Nobel prize for chemistry for 1928 was awarded to Adolf Windaus “for his studies on the constitution of the sterols and their connection with vitamins” (1), the first person to receive an award mentioning vitamins. What was the contribution Windaus made to our knowledge of vitamins that deserved the highest scientific accolade? The vitamin in question was vitamin D. It had a long history be...

One indicator of the success development in health sector can be seen from level maternal and infant mortality rates. cause death infants toddlers is neurological diseases including eye disease. Around world among preschoolers there are an estimated 6-7 million cases xerophthalmia each year, approximately 10% them suffer corneal damage. Among those who suffered damage 60% died within one 25% be...

Background: Association of Addison's disease with connective tissue diseases such as scleroderma and Sjogren have been rarely reported. Anti-centromere antibody (ACA) has been associated with exocrine gland dysfunction in anti-Ro, anti-La negative Sjogren’s syndrome and may be one of the causes of xerostomia in community. The purpose of this article was to introduce a rare case of scleroderma-S...

Sjögren's syndrome is an autoimmune exocrinopathy which manifests itself with dryness of the eyes and the oral cavity. These symptoms comprise a so-called sicca syndrome (xerostomia and xerophthalmia). Two forms of this disease may be distinguished: primary Sjögren's syndrome which affects salivary glands and secondary Sjögren's syndrome with other autoimmune diseases present such as rheumatoid...

The studies of the past decade have revealed the fact that the adequate diet of the higher animals must contain protein of the type known as "complete," by which we mean a protein yielding all the amino-acids that are required in the nutrition of an animal. It must contain, in the form of suitable salts, at least nine of the inorganic elements, namely, calcium, magnesium, sodium, potassium, iro...

Introduction: Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by painful cutaneous ulcers. It can appear as primary or idiopathic illness or secondary to a systemic disease. Only few cases in the literature reported the association between PG and Sjögren disease, which manifests primarily with sicca symptoms. This paper describes the remarkable initial clinical present...

UNLABELLED Diagnosis of Sjögren's syndrome (SS) is complex and the usefulness of labial minor salivary glands biopsy in this process remains controversial. OBJECTIVE to evaluate the clinical and laboratorial profile and histological features on labial minor salivary glands from patients under investigation of SS. STUDY DESIGN clinical charts from 38 patients under suspicion of SS and submit...

OBJECTIVE SS is an autoimmune disease characterized by salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eyes (xerophthalmia). Anti-muscarinic acetylcholine type-3 receptor (anti-M3R) autoantibodies have been shown to be a good serum marker in primary SS (pSS). The aim of this study was to assess the clinical correlations of anti-M3R-derived peptide antibodies in...

OBJECTIVE To assess the prevalence of anti-Ro/SSA in RA and to analyse clinical and serological features of anti-Ro/SSA positive patients with RA. METHODS 195 consecutive patients affected by RA were studied by counterimmunoelectrophoresis and ELISA for the detection of anti-Ro/SSA antibodies. Anti-Ro were found in 12 patients, with a prevalence of 6%. These 12 patients were pooled with other...