BACKGROUND Essential Thrombocythemia (ET) and Primary Myelofibrosis (PMF) are Chronic Myeloproliferative Neoplasms (MPN) characterized by clonal myeloproliferation/myeloaccumulation without cell maturation impairment. The JAK2 V617F mutation and PRV1 gene overexpression may contribute to MPN physiopathology. We hypothesized that deregulation of the apoptotic machinery may also play a role in th...

The oncogenic protein Bcl-2 functions as a potent inhibitor of programmed cell death. This survival activity has been shown in some settings to be influenced by the Bcl-2 phosphorylation state. It has been demonstrated that treatment with microtubule-targeted agents results in phosphorylation of both Raf-1 kinase and Bcl-2. The Bcl-2-related family member Bcl-xL also exhibits a death suppressiv...

We propose a decentralized receiver for extra-large multiple-input multiple-output (XL-MIMO) arrays. Our method operates with no central processing unit (CPU) and all the signal detection tasks are done in distributed nodes. exploit combined message-passing framework to design an uncoordinated scheme that overcomes three major challenges XL-MIMO systems: computational complexity, scalability no...

Abstract. Atmospheric CO2 mole fractions are observed at Beijing (BJ), Xianghe (XH), and Xinglong (XL) in North China using Picarro G2301 cavity ring-down spectroscopy instruments. The measurement system is described comprehensively for the first time. geographical distances among these three sites within 200 km, but they have very different surrounding environments: BJ inside megacity; XH subu...

Inherited Retinal Dystrophies (IRDs) are a group of rare diseases with prevalence 1:3000-4000 people. They genetic, primarily affecting retinal photoreceptors and epithelial pigmentary cells, lead to neurodegeneration finally apoptosis. In 2021, we published our global results obtained in registry at the Fundación Jiménez Díaz University Hospital (Madrid, Spain) from 1991 August 2019. Now, aime...

Algebraic attacks are studied as a potential cryptanalytic procedure for several cryptographic primitives. In an algebraic attack on a cipher, one expresses the encryption function as a system (usually overdefined) of multivariate polynomial equations in the bits of the plaintext, the ciphertext and the key, and subsequently solves the system for the unknown key bits from the knowledge of one o...

Myocardial Infarction (MI), also known as heart attack, is a life-threatening form of disease that leading cause death worldwide. Its recurrent and silent nature emphasizes the need for continuous monitoring through wearable devices. The device solutions should provide adequate performance while being resource-constrained in terms power memory. This paper proposes an MI detection methodology us...

Massive multiple-input-multiple-output (M-MIMO) features a capability for spatial multiplexing of large number users. This becomes even more extreme in extra-large (XL-MIMO), variant M-MIMO where the antenna array is very size. Yet, problem signal processing complexity further exacerbated by XL size array. The basic boils down to sparse system linear equations that can be addressed randomized K...