Background: Cancer is a public health emergency. It has high mortality rate despite numerous studies on pharmaceutical therapies. Chimeric antigen receptor-natural killer (CAR-NK) cells are promising immunotherapy that could be used to treat cancer, especially leukemia. However, the evidence still unclear. Thus, this systematic review aims summarize regarding use of CAR-NK as therapy for Method...

Transformation of Streptomyces galilaeus ATCC 31133 with the aklavinone 11-hydroxylase gene (dnrF) resulted in the production of many red pigments. The new metabolites were purified and their structures were determined as 11-hydroxylated aclacinomycin A, B and T by spectral analysis. This result indicated that the dnrF was stably expressed in the strain S. galilaeus ATCC 31133 to give rise to h...

The human acute promyelocytic leukemia cell line HL-6O is induced to differentiate into morphologically and functionally mature monocytelike cells by incubation with a combination of 10 nmol/L retinoic acid (RA) and various concentrations of recombinant immune interferon (rIFN-”y). These induced cells show marked increases in antibody-dependent cellular cytotoxicity (ADCC). antibody-coated eryt...

The human acute promyelocytic leukemia cell line HL-6O is induced to differentiate into morphologically and functionally mature monocytelike cells by incubation with a combination of 10 nmol/L retinoic acid (RA) and various concentrations of recombinant immune interferon (rIFN-”y). These induced cells show marked increases in antibody-dependent cellular cytotoxicity (ADCC). antibody-coated eryt...

The y-ray sensitivity of skin fibroblasts from six members of a cancer family was investigated using a colony-forming assay. Fibroblasts from the three members with cancer (two sisters with acute myelogenous leukemia and the mother with cervical carcinoma) showed a significant (p < 0.05) increase in radiosensitivity, while three members without cancer (the father and two sons) showed a normal r...

The human acute promyelocytic leukemia cell line HL-6O is induced to differentiate into morphologically and functionally mature monocytelike cells by incubation with a combination of 10 nmol/L retinoic acid (RA) and various concentrations of recombinant immune interferon (rIFN-”y). These induced cells show marked increases in antibody-dependent cellular cytotoxicity (ADCC). antibody-coated eryt...

&#x0D; Acute Lymphocytic leukemia (ALL) is the most common childhood malignancy, CNS involvement occurs in 3-5% of patients. We present a case 14-year-old boy who presented to us with nighttime fever, headache, and right-sided focal fits. Reports showed decreased platelets, increased WBC predominant eosinophils imaging subgaleal, epidural subdural collection. Bone marrow biopsy CSF analysis wer...

Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing admission to leukemic cell. Besides high antitumor effect, drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, hepatotoxicity. For safety profile im...

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematological disease. Modern polychemotherapy protocols allow achieving a 5-year overall survival of 60–90 % in different age groups, however, relapses and refractory forms T-ALL remain incurable. Over the past decades, pathogenesis this variant leukemia has been studied many trials, it found that various signaling pathways ...