BACKGROUND By the formation of cGMP, nitric oxide (NO)-sensitive guanylyl cyclase (GC) acts as the effector for the signaling molecule NO and mediates the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The compounds YC-1 and BAY 41-2272 are regarded as NO-independent activators and sensitizers of NO-sensitive GC. In vivo effects, for example, lowering blood pre...

In this paper a simple turning point (y = yc, A = Ac) of the parameterdependent Hammerstein equation y(t) = f(t) + X k(t,s)g(s,y(s))ds, te[a,b], is approximated numerically in the following way. A simple turning point (z = zc, X = Xe) of an equivalent equation for z(t) := Xg(t, y(t)) is computed first. This is done by solving a discretized version of a certain system of equations which has (2e,...

The dimeric enzyme glutathione S-transferase B is composed of two dissimilar subunits, referred to as Ya and Yc. Transferase B (YaYc) and two other transferases that are homodimers of the individual Ya and Yc subunits were purified from rat liver. Inhibition of these three enzymes by Indocyanine Green, biliverdin and several bile acids was investigated at different values of pH (range 6.0-8.0)....

Overexpression of HIF-1α, a transcription factor responsive to hypoxia, is frequently observed in malignant tumors, which sometimes show resistance to chemotherapy and radiation therapy. Consequently, decrease of HIF-1α through virotherapy offers a logical strategy for the treatment of aggressive tumors. In this study, we found that infection with the oncolytic H-1 parvovirus decreased HIF-1α p...

Cut-out data from 2,550 steer carcasses representing British, Continental and Zebu breeding were analyzed to evaluate yield grade classes based on three equations: 1) Ya = 2.5 + .984 AFT + .0084 HCW - .05 REA + .2 KPF; 2) Yb = same as Ya with intercept changed to 3.2 and KPF deleted; 3) Yc = 3.0 + .984 AFT + .0041 HCW - .03 REA, as proposed by USDA in 1984; where AFT = adjusted fat thickness (c...

This is a short and very elementary introduction to causal inference in social science applications targeted to machine learners. I illustrate the techniques described with examples chosen from the economics and marketing literature. 1 A motivating problem 1 Suppose you are given some data on ad spend and product sales in various 2 cities and are asked to predict how sales would respond to a co...

Many Constraint Programming models use integer cost variables aggregated in an objective criterion. In this context, some constraints involving exclusively cost variables are often imposed. Such constraints are complementary to the objective function. They characterize the solutions which are acceptable in practice. This paper deals with the case where the set of costs is a sequence, in which h...

PURPOSE The prostate-specific membrane antigen (PSMA) is a surface glycoprotein overexpressed on malignant prostate cells, as well as in the neovasculature of many tumors. Recent efforts to target PSMA for imaging prostate cancer rely on suitably functionalized low-molecular-weight agents. YC-27 is a low-molecular-weight, urea-based agent that enables near-infrared (NIR) imaging of PSMA in vivo...

The performance of a container terminal depends on many aspects of operations. This paper focuses on the optimal sequencing of a yard crane (or YC for short) for serving a fleet of vehicles for delivery and pickup jobs. The objective is to minimize the average vehicle waiting time. While heuristic algorithms could not guarantee an optimal solution, a conventional mathematical formulation such a...