Award Number: W81XWH-08-1-0108 TITLE: The role of eIF4E activity in breast cancer PRINCIPAL INVESTIGATOR: Thomas A Hughes CONTRACTING ORGANIZATION: University of Leeds Leeds LS2 9-0000 REPORT DATE: August 2010 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT:  Approved for public release; distribution ...

Fatigue is a recognised problem in the transport industry. It has been attributed to two main influences: time of day and the time since last sleep. While the role of these two influences in producing fatigue is not disputed, there is less agreement on how they interact with one another. The aim of this study was to examine the relative effects of time of day and sleep deprivation on fatigue an...

Prior studies have shown that the IT innovation capability, a company's ability to innovate systematically with IT, is not easily replicated (persistent), and the persistence tends to be more pronounced during periods when economy-wide IT budgets are declining (hard IT budgets), such the post-Y2K period. Building on resource based view we argue that companies that systematically innovate with I...

Award Number: W81XWH-08-1-0108 TITLE: The role of eIF4E activity in breast cancer PRINCIPAL INVESTIGATOR: Thomas A Hughes CONTRACTING ORGANIZATION: University of Leeds Leeds LS2 9-0000 REPORT DATE: August 2010 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT:  Approved for public release; distribution ...

We examine the state of game theory. Many important questions have been answered, and game theoretic methods are now central to much economic investigation. We suggest areas where further advances are important, and argue that models of learning and of social preferences provide promising routes for improving and widening game theory’s predictive power, while preserving the sucesses of existing...

To get some intuition, we begin with the group of real numbers R under addition. A trivial upper bound for the size of a sum set is |A + A| ≤ |A| 2+|A| 2 (equality is obtained when every pair of elements of A have a distinct sum). If we build A by taking elements of R at random, then we expect |A+A| to be very close to this upper bound, since the probability of a1+a2 = a3+a4 is very small (wher...

The Clifford tori in S constitue a one-parameter family of flat, two-dimensional, constant mean curvature (CMC) submanifolds. This paper demonstrates that new, topologically non-trivial CMC surfaces resembling a pair of neighbouring Clifford tori connected at a sub-lattice consisting of at least two points by small catenoidal bridges can be constructed by perturbative PDE methods. That is, one ...

The retro-cue effect (RCE) describes superior working memory performance for validly cued stimulus locations long after encoding has ended. Importantly, this happens with delays beyond the range of iconic memory. In general, the RCE is a stable phenomenon that emerges under varied stimulus configurations and timing parameters. We investigated its susceptibility to dual-task interference to dete...

We derive a new representation of Lagrangian subspaces in the form ImΠT [ I X ] , where Π is a symplectic matrix which is the product of a permutation matrix and a real orthogonal diagonal matrix, and X satisfies |Xij | ≤ { 1 if i = j, √ 2 if i = j. This representation allows us to limit element growth in the context of doubling algorithms for the computation of Lagrangian subspaces and the sol...