edema and other systemic complications were frequently obseryed in both drug-induced and spontaneous YNS asseciated with RA. Although the nail changes and systemie complications are probably due to different causes in drug-induced YNS, a careful search for systemic eomplications are necessarr in patients who deyelop nail changes. The exact mechanism of nail growth retardation is not understood ...

INTRODUCTION Nail-patella-syndrome (NPS) is a rare autosomal-dominant inherited disease with pathologies of nails, skeleton, kidneys, and eyes. Linkage to a mutated gene was found. It codes for the transcription-factor LMX1B. In most cases knees are symptomatic. Patients have hypoplastic patellae, which are laterally subluxated. In those individuals a sagittal trochlear fibrous septum was found...

Nail-patella syndrome is a rare autosomal dominant disorder with characteristic skeletal and renal abnormalities, most commonly dysplastic nails, hypoplastic/absent patellae, and asymptomatic urinary abnormalities Box 3 Final diagnosis Nail-patella syndrome or hereditary onycho-osteodysplasia. A 52-year-old man presented with a history of colicky epigastric pain, intermittent upper abdominal di...

BACKGROUND Laser therapies have been Food and Drug Administration approved for temporary nail plate clearance; however, there is minimal evidence of their long-term efficacy. OBJECTIVE We sought to evaluate the clinical and mycological clearance of toenails treated with 1064-nm neodymium:yttrium-aluminum-garnet laser versus no treatment. METHODS This was a randomized, controlled, single-cen...

The objective is to identify nail unit changes associated with connective tissue diseases (CTD) and evaluate their frequency. We carried a prospective study between March 2012 and March2013 in our department. All patients with CTD were included. A clinical examination of the fingernails was done by the same dermatologist. Nail features were noted and classified and photos taken. Thirty nine pat...

BACKGROUND Hair is susceptible to exogenous sources of discoloration. There are several exogenous etiologies for yellow hair discoloration, including tobacco. PURPOSE We describe the clinical features of five men with tobacco-associated yellow discoloration of their mustache, a condition known as "smoker's mustache." We also review the characteristics of men with tobacco-associated yellow dis...

Psoriatic arthritis has now gained general acceptance as an entity distinct from rheumatoid disease (Garrod and Evans, 1924; McEwen, Ziff, Carmel, DiTata, and Tanner, 1958; Wright, 1961). Distal interphalangeal joint involvement is a prominent feature of psoriatic arthritis (Avila, Pugh, Slocumb, and Winkelmann, 1960; Bauer, Bennett, and Zeller, 1941; Sherman, 1952), but not of rheumatoid arthr...

Chronic iron deficiency can be associated with nail deformities like Koilonychia and Platynychia. It can also be associated with esophageal webs (Plummer-Vinson syndrome or Patterson-Brown-Kelly syndrome) causing dysphagia in the patient. Though the pathogenesis of this association remains anecdotal and presence of these physical findings should prompt the clinician towards considering chronic ...