Reactive oxygen intermediates and nitric oxide modulate the contractile function of skeletal muscle fibers, possibly via direct interaction with the Ca2+ release channel. Oxidants produce disulfide bonds between subunits of the Ca2+ release channel tetramer, and this is accompanied by an increase in channel activity. The sulfhydryl alkylating agent N-ethylmaleimide has three distinct effects on...

A broadcast channel with one sender and two receivers is considered. Three independent messages are to be transmitted over this channel: one common message which is meant for both receivers, and one private message for each qf them. The coding theorem and strong converse for this communication situation is proved for the case when one of the private messages has rate zero. I. I -NTRODUCTION W E...

Alkaloid-modified, voltage-dependent sodium channels from lobster walking leg nerves were studied in planar neutral lipid bilayers. In symmetrical 0.5 M NaCl the single channel conductance of veratridine (VTD) (10 pS) was less than that of batrachotoxin (BTX) (16 pS) modified channels. At positive potentials, VTD- but not BTX-modified channels remained open at a flickery substate. VTD-modified ...

out the whole region will provide a final answer to the spin question and information on the parity. In particular, the energy dependence of the Z w+ differential cross sections must be established carefully, because we cannot rule out the possibility that the large value of A, (Z ~+) at 760 MeV/c is due mainly to nonresonant terms. If this is the case, the value of x& would be much smaller, an...

The blocking actions of Fe 2÷, Co 2÷, and Ni 2÷ on unitary currents carried by Ba 2÷ through single dihydropyridine-sensitive Ca 2÷ channels were recorded from cell-attached patches on myotubes from the mouse C2 cell line. Adding millimolar concentrations of blocker to patch electrodes containing 110 mM BaCI z produced discrete excursions to the closed channel level. The kinetics of blocking an...

Using deconvolved confocal microscopy of fluorescently labeled markers for z-disks, t-tubules and ryanodine receptors, we have examined sarcomere organization in cardiac myocytes from rat, rabbit and human. We show that sarcomeres exhibit dislocations in registration and occasionally more complex helicoidal topology. This organization was present at both slack ( approximately 1.8 microm) and lo...

The mechanism by which a threshold may capture a resonance is examined. It involves a threshold cusp interfering constructively with either or both (i) a resonance produced via confinement, (ii) attractive tand u-channel exchanges. The f0(980), X(3872) and Z(4430) are studied in detail. The f0(980) provides a valuable model of the locking mechanism. The X(3872) is too narrow to be fitted by a c...

By modeling the statistical evolution of an avalanche created by 20 keV protons impacting the input surface of a z-stack microchannel plate ~MCP! detector, the mean secondary electron yield gC of avalanche electrons propagating through a MCP channel is measured to equal 1.37 for 760 V per MCP in the z stack. This value agrees with other studies that used MCP gain measurements to infer gC . The ...

One of the major limitations on transmission speed per single-channel in dispersion-managed soliton (DMS) systems is soliton interactions between neighboring pulses induced by large pulse breathing within one dispersion-management period [1]. To o vercome this limitation, densely dispersion-managed soliton (DDMS) system was recently proposed, and it is numerically demonstrated that 80 Gb/s soli...

We study the discrete memoryless Z-interference channel (ZIC) where the transmitter of the pair that suffers from interference is cognitive. We first provide upper and lower bounds on the capacity of this channel. We then show that, when the channel of the transmitter-receiver pair that does not face interference is noiseless, the two bounds coincide and therefore yield the capacity region. The...