Introduction . Rehabilitation programs for patients with vertebral fractures (VF) underlying osteoporosis (OP) include various methods. Pharmacological therapy should be prescribed to all who have undergone pathological VF OP reduce the risk future fractures. Objective To study effect of intravenous infusions zoledronic acid at a dose 5 mg once year compared oral bisphosphonates on long-term ou...

The successful use of surgical and medical methods jaw bone tissue restoration has been convincingly confirmed in clinical practice. At the same time, technologies are being developed to improve osseointegration dental implants patients with osteoporosis. various implant coatings, as well systemic therapy, demonstrate emergence new directions treatment partial or complete secondary edentulism c...

BACKGROUND Bone grafts are frequently used in orthopaedic surgery. Graft remodelling is advantageous but can occur too quickly, and premature bone resorption might lead to decreased mechanical integrity of the graft. Bisphosphonates delay osteoclastic bone resorption but may also impair formation of new bone. We hypothesize that these effects are dose dependent. In the present study we evaluate...

The results of the well-conducted trial by Saad et al. (1) have prompted many to consider routine use of zoledronic acid to reduce the incidence of skeletal-related events in minimally symptomatic or asymptomatic men with hormone-refractory prostate cancer. This is a somewhat troublesome proposition, because all men in this situation are not at risk of a skeletal-related event. In the placebo a...

BACKGROUND In a phase III trial in patients with castration-resistant prostate cancer (CRPC) and bone metastases, denosumab was superior to zoledronic acid in reducing skeletal-related events (SREs; radiation to bone, pathologic fracture, surgery to bone, or spinal cord compression). This study reassessed the efficacy of denosumab using symptomatic skeletal events (SSEs) as a prespecified explo...

Abstract: SAPHO syndrome is characterized with a set of symptoms including skin lesions, osteoarticular manifestations like aseptic osteitis (of the anterior chest wall or other skeletal sites), peripheral synovitis. Due to lack randomized clinical trials and low prevalence condition, there are no established treatment guidelines for syndrome. Here, we report case sternum palmoplantar pustulosi...

OBJECTIVE This review summarizes recent findings on the therapeutic benefits of biphosphonates in patients with advanced prostate or renal cell carcinoma (RCC). The role of biphosphonates in ADT-induced osteoporosis and delay of skeletal-related events (SREs) in metastatic bone disease is discussed. A brief overview on the proposed modes of action is given. METHODS Literature search of PubMed...

INTRODUCTION Osteonecrosis of the jaw is a serious side effect in patients receiving nitrogen-containing bisphosphonates intravenously due to malignant diseases. Albeit far less frequently, osteonecrosis of the jaw has also been reported to occur due to the oral administration of nitrogen-containing bisphosphonates due to osteoporosis. Annual infusions of zoledronic acid have been recommended i...