Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in this study. The pregnant and nonpregnant rabbits received ZNM orally at a dose ...

The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA). Recently, topiramate and lamotrigine have also been shown to be effective. The objective of this study was to evaluate the efficacy and tolerability of zonisamide (ZNS) in the treatment of JME. We retrospectively analyzed the records of 15 patients (three M, 12 F, ages 11-20 years) diagnosed with JME at our inst...

Fever ≥38.5°C No/U Yes 0 Enlarged lymph nodes No/U Yes 0 Eosinophils No/U 0.7–1.499 × 109l–1 ≥ 1.5× 109l–1 1 Atypical lymphocytes No/U Yes 1 Skin involvement 2 Skin rash extent (% body surface area) No/U > 50% Skin rash suggesting DRESS No/U Yes Biopsy suggesting DRESS No Yes/U Organ involvementa 2 Liver No/U Yes Yes Kidney No/U Yes No/U Lung No/U Yes Yes Muscle/heart No/U Yes No/U Pancreas No/...

The term seizures includes a wide array of different disorders with variable etiology, which currently represent one the most important classes neurological illnesses. As consequence, many antiepileptic drugs (AEDs) are available, exploiting activity mechanisms and providing levels performance in terms selectivity, safety, efficacy. AEDs among psychoactive frequently involved therapeutic drug m...

OBJECTIVE The objective of this study is to evaluate the efficacy and safety of zonisamide (ZNS) for the treatment of idiopathic generalized epilepsies (IGEs). METHODS Thirteen patients with different types of IGEs who were treated with ZNS between the years 2006 and 2008 were identified. Efficacy and tolerability were assessed at months 6 and 12 post-treatment. Response was defined as a 50% ...