background :impact of substance abuse on outcome of hospitalized patients with acute myocardial infarction (mi) is a frequent question. available studies show disagreements over its impact, thus we performed this study to find a clear answer.   methods : in a cross sectional study, 304 patients (include 152 consecutive opium dependents and equal number of independents) with acute mi admitted to...

glutathione s-transferases (gsts; ec: 2.5.1.18) are ubiquitous multifunctional enzymes, which play a key role in cellular detoxification. functional genetic polymorphisms in genes encoding gstm1 (a member of gst class mu; omim: 138350), and gstt1 (a member of gst class theta; omim: 600436) have been well defined. the functional null alleles of gstm1 and gstt1 represent deletions of gstm1 and gs...

background and objective: today, opioids are used to control and relieve acute and chronic pain. however, the incidence of both tolerance and dependence phenomena for these drugs is a major problem. so, in this study, the combination effect of haloperidol and methadone on the acquisition and expression of morphine dependence and tolerance was examined.    materials and methods: ninety-eight mic...

long-term exposure to opiates induces physical dependence and tolerance. the main goal of this study was to evaluate the effects of dextromethorphan and midazolam and their combination on morphine tolerance and dependence in mice. different groups of mice were rendered randomly and received morphine (50 mg/kg, sc), morphine (50 mg/kg, sc) + dextromethorphan (25,50 or 75 mg/kg, ip), morphine (50...

one of the most important behavioral aspects in relationship among the main members of marketing channel is the issue of power and dependence that here we have looked through the source of power and countervailing power and we have considered reputation independence, sale and profits and marketing role dependence. in this research relationship between the two main marketing channel members in h...

buprenorphine (subutex) has been used to treat opioid dependency in the past 16 years. subutex (or buprenorphine hydrochloride) was approved by the singapore's ministry of health (moh) in 2000 as a substitution treatment for opiate-dependent drug abusers within the framework of medical, social and psychological treatments. it was subsequently introduced into the singapore market in 2002. i...

results there was significant reduction in anger symptoms of drug-dependent individuals after gross model based emotion regulation training (ert) (p < 0.001). moreover, the effectiveness of the training on anger was persistent in the follow-up period. conclusions symptoms of anger in drug-dependent individuals of this study were reduced by gross model-based emotion regulation strategies trainin...

background and aims: safflower (carthamus tinctorius l.)from asteraceae family has different biological activities including analgesic, antidepressant, anti-inflammatory, antispasmodic and neuroprotective effects. this study designed to evaluate its effect on naloxone -induced morphine withdrawal signs. methods: in this experimental study, male nmri mice (25-30 g) were randomly divided into 5 g...

background several empirical studies have shown the attitude of smokers to formulate judgments based on distortion in the risk perception. this alteration is produced by the activation of the optimistic bias characterized by a set of the unrealistic beliefs compared to the outcomes of their behavior. this bias exposes individuals to adopt lifestyles potentially dangerous for their health, under...

background: 7-lif: mg,cu,p (gr-207a) is one kind of thermo-luminescent dosimeters (tld) which can be used in diagnostic radiology and radiotherapy applications. because of having suitable properties such as good sensitivity, small size and being tissue equivalent, thermo-luminescent dosimetry has been one of the most important techniques in medicine over many years. choosing a correct energy fo...