Abstract—Cefixime, a BCS class II drug, is insoluble in water but freely soluble in acetone and in alcohol. The aqueous solubility of cefixime in water is poor and exhibits exceptionally slow and intrinsic dissolution rate. In the present study, cefixime and βCyclodextrin (β-CD) solid dispersions were prepared with a view to study the effect and influence of β-CD on the solubility and dissoluti...

Purpose: To formulate fast-disintegrating tablets (FDT) of rosuvastatin calcium (RST) using βcyclodextrin (CD) and different superdisintegrants to enhance their solubility. Methods: A total of 15 FDT formulations of RST were prepared using three different techniques. The FDTs were evaluated for micromeritic properties, as well as by Fourier transform infrared spectroscopy (FTIR), thermal analys...

Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement, suggesting that a similar manipulation would alter cochlear mechanics. We examined cochlear function before and after depletion of membrane cholesterol with methyl-βcyclodextrin (MβCD) in an excised guinea pig temporal bone preparation. ...

Electrospun scaffolds of neat poly-ε-caprolactone (PCL), poly-ε-caprolactone/βcyclodextrin inclusion complex (PCL/β-CD) and poly-ε-caprolactone amino derivative inclusion complex (PCL/β-CD-NH2) were prepared by the electrospinning technique. The obtained mats were analyzed by a theoretical model using the Hartree–Fock method with an STO-3G basis set, and characterized by X-ray diffraction (XRD)...

While 2-amino-4-(4-chlorophenyl)thiazole (AT) drug and thiazole derivatives have several biological applications, these compounds present some drawbacks, such as low aqueous solubility and instability. A new complex of βCD-AT has been synthesized to increase AT solubility and has been used as a substrate for the deposit of solid-state AuNPs via magnetron sputtering, thus forming the βCD-AT-AuNP...

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...

Efavirenz belongs to Class II under BCS and exhibit low and variable bioavailability due to its poor aqueous solubility. As such it needs enhancement in the dissolution rate and bioavailability to derive its maximum therapeutic efficacy. The objective of the present investigation is to study the complexation of efavirenz with two cyclodextrins, βcyclodextrin (βCD) and hydroxypropyl β-cyclodextr...

This study investigated the potential application of formulating pharmaceutical products using microwave heating methods alongside associated analytical investigations. Firstly, the interaction between three functionally related drugs, ibuprofen, ketoprofen and flurbiprofen, with two distinct forms of cyclodextrin at three temperatures, 298, 303 and 310K was investigated using isothermal titrat...

Omega-3 fatty acids are used in both nutraceuticals and pharmaceuticals in the form of triglycerides and ethyl esters. Administration forms available for omega-3 oil include bulk oil, soft gel capsules, emulsions and some powder compositions. However, the niche omega3 tablets have so far remained unexplored. In the present work direct compaction grade powders comprising omega-3 oil as triglycer...

The best metabolic conditions for the biodegradation of hydrocarbons by a selected microbial consortium from a natural soil were investigated in order to improve the efficiency of bioremediation processes for cleaning of polluted waters and soils. Phenanthrene is one of the most recalcitrant pollutants to microbial decomposition and most difficult to remove. A microbial consortium was selected ...