Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3-8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess ...

A convenient base-mediated two-step synthesis of cotinine analogs and a one-pot base-free synthesis of iso-cotinine derivatives featuring an Ugi-4CR/cyclization protocol are reported. These approaches exploit the reactivity of the peptidyl position present in the Ugi adducts, allowing the facile construction of the γ-lactam core, as well as the introduction of a N-substituted methyl group into ...

Glutathione is a tripeptide (l-γ-glutamyl-l-cysteinyl-glycine) thiol compound existing in many bacteria and maintains a proper cellular redox state, thus protecting cells against toxic substances such as reactive oxygen species. Polyamines (spermine and spermidine) are low-molecular-weight aliphatic polycations ubiquitously presenting in all living cells and modulate many cellular functions. We...

We report a stereoselective, multicomponent catalytic carbonylative approach to new class of α,β-unsaturated γ-lactam derivatives with potential biological activity, that are, alkyl (Z)-2-(2-oxopyrrolidin-3-ylidene)acetates. Our method is based on the assembly readily available building blocks, namely, homopropargylic amines, carbon monoxide, an alcohol, and oxygen (from air). These simple subs...

We consider the Gamma limit of the Abelian Chern-Simons-Higgs energy

In this note, we present a Γ-convergence type result for ferromagnetic films. We propose a model of films for which we could ensure the strong convergence of minimizers when the exchange parameter vanishes. In this model, the plate thickness is kept constant and the magnetization stays constant in the thickness of the film.