Insulin resistance may enhance the neointima formation via increased oxidative stress. However, clinical trials investigating the benefit of antioxidant therapy with α-tocopherol showed negative results. Recent studies showed that chemical characteristics of γ-tocopherol are distinct from those of α-tocopherol. We hypothesized that γ-tocopherol is superior to α-tocopherol in preventing the neoi...

BACKGROUND Vitamin E compounds exhibit prostate cancer preventive properties experimentally, but serologic investigations of tocopherols, and randomized controlled trials of supplementation in particular, have been inconsistent. Many studies suggest protective effects among smokers and for aggressive prostate cancer, however. METHODS We conducted a nested case-control study of serum α-tocophe...

Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in...

The incidence of prostate cancer is increasing and there is continuing research into possible preventive treatments. Vitamin E, an antioxidant, has been studied as a chemoprotective agent in recent literature with α-Tocopherol being the most prominently studied. Although α-Tocopherol is found in highest concentration in the body, there are seven other isomers of vitamin E as tocopherols and toc...

Glioblastoma is associated with poor prognosis with a median survival of one year. High doses of ionizing radiation is the only established exogenous risk factor. To explore new potential biological risk factors for glioblastoma, we investigated alterations in metabolite concentrations in pre-diagnosed serum samples from glioblastoma patients diagnosed up to 22 years after sample collection, an...

Extended use of plant ingredients in Atlantic salmon farming has increased the need for knowledge on the effects of new nutrients and contaminants in plant based feeds on fish health and nutrient-contaminant interactions. Primary Atlantic salmon hepatocytes were exposed to a mixture of PAHs and pesticides alone or in combination with the nutrients ARA, EPA, α-tocopherol, and γ-tocopherol accord...

In this study, the oil contents, fatty acid composition and tocopherol contents of sesame seed and oils belong to different countries were determined. The oil contents of materials changed between 49.22% (India) and 56.16% (Nigeria-Kanu). The major saturated fatty acids in sesame seed oils were palmitic (6.06-9.03%), stearic (5.29-6.42%) acids with small 20:0 (0.19-0.71%) acids. The main un...

Changes in antioxidant properties and degradation of bioactives in palm oil (PO) and rice bran oil (RBO) during deep-frying were investigated. The alpha (α)-tocopherol, gamma (γ)-tocotrienol and γ-oryzanol contents of the deep-fried oils were monitored using high performance liquid chromatography, and antioxidant activity was determined using 2-diphenyl-1-picryl hydrazyl (DPPH) radical scavengi...

Research on new, untapped seed oil sources is receiving increased attention. In this study, 18 different samples of Tilia cordata and platyphyllos from various locations in Slovenia were collected was extracted. The compositions triglyceride fatty acids unsaponifiable compounds determined using GC-MS, while antioxidant activity evaluated the DPPH method. content seeds varied significantly, 9.1%...