Delta-9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, is known to suppress the immune responses to bacterial, viral and protozoan infections, but its effects on fungal infections have not been studied. Therefore, we investigated the effects of chronic Δ9-THC treatment on mouse resistance to systemic Candida albicans (C. albicans) infection. To determine the outcome of ...

Methamphetamine (METH) is a potent psychostimulant with neurotoxic properties. Heavy use increases the activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrites, microglia stimulation, and induces hyperthermia and anorectic effects. Most METH recreational users also consume cannabis. Preclinical studies have shown that natural (Δ9-tetrahydrocannabinol, Δ9-THC) and synthe...

Abstract The use of hemp ( Cannabis sativa L.) essential oil (EO) has shown a significant increase in interest and during recent years. In this work, new simple reversed-phase HPLC with photodiode-array (PDA) detector method been developed optimized for the detection quantification cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinol (CBN), Δ9-tetrahydrocannabinol (Δ9-THC), Δ9-tetrahydrocan...

PURPOSE OF REVIEW The lack of clarity about the effect of cannabis use on cognition may be attributable to the considerable heterogeneity among studies in terms of cannabis composition. This article selectively reviews studies examining the distinctive effects of cannabinoids on human cognition, particularly those of delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). RECENT FINDINGS...

Abstract The aim of this study was to extract and quantify cannabinoids from female inflorescences Cannabis sativa L. three altitudinal floors Peru, by optimizing the amplitude, time, methanol concentration in ultrasound-assisted extraction required maximize cannabidiol (CBD), delta-9-tetrahydrocannabinol (Δ9-THC) content, yields. Optimal conditions were determined response surface central comp...