Hücrenin hayatta kalmasıyla ilgili hücre içi yollar, gelişim ve nörodejeneratif bozukluklar sırasında nöronal fizyolojiyi düzenler. Bu süreçlerde önemli bir rolle ortaya çıkan yollardan biri Nüklear Faktör-κB (NF-κB) sinyal yolağıdır. yolağın aktivitesi, NF-κB transkripsiyon faktörlerinin nüklear translokasyonuna anti-apoptotik gen ekspresyonunun düzenlenmesine yol açar. Farklı uyaranlar, farkl...

signaling amp-activated protein kinase (ampk), an energy sensing enzyme, has been implicated in controlling inflammation. in this study we investigated whether activation of ampk by metformin could protect the lung from lipopolysaccharide (lps)-induced acute injury by inhibitingng tlr4 pathway. male wistar rats were randomly divided into 3 groups (n=6): control group received normal saline (0.5...

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effec...

The purpose of this research is to see if there a link between diabetes type 2 complications and the level nuclear factor kappa B (NF-κB) overexpression.
 Ninety blood samples were collected from individuals divided into three groups, each group involved thirty samples: first representing with (hypertensive ) ,the second diabeteswith cardiovascular diseases), last was represented by contro...

background: regular aerobic exercise improves the background: regular aerobic exercise improves the inflammatory status in different lung diseases. however, the effects of long-term aerobic exercise on the lung response have not been investigated. the present study evaluated the effect of aerobic exercise on the lung inflammatory. m aterials and methods: 12 adult male wistar rats were divided t...

Background and Aim. Daphnetin, an active monomer ingredient extracted from D. marginata, is proved to have anti-inflammatory antioxidant effect. The aim of this study explore the effect possible mechanism daphnetin on acute lung injury (ALI) associated with pancreatitis (AP) in mice. Methods. A total 36 mice were randomly assigned into three groups: control group, AP group. mouse model was indu...

NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind regulation outcome remains important area immunology research. Here we briefly discuss role regulating cell fate decisions at various times path B development, activation, gener...

Objectives. The effects of Kluyveromyces marxianus on high-fat diet- (HFD-) induced kidney injury (KI) were explored. Methods. HFD-induced KI model was established using male C57BL/6 mice and treated with K. JLU-1016 acid-resistant (AR) strain JLU-1016A. Glucose tolerance evaluated via an oral glucose test (OGTT). measured Hematoxylin Eosin (H&E) staining terminal deoxynucleotidyl transfera...

Abstract The aim of this study was to examine whether there are differences in adrenomedullary function respect the left and right sides chronic stress conditions. We investigated how isolation (CSI 12 weeks) affected protein levels key enzymes involved adrenaline (A) synthesis (phenyl ethanolamine N-methyltransferase -PNMT), storage (vesicular monoamine transporters 2 - VMAT2) degradation (cat...

our previous study reported that lactobacillus acidophilus ( l.acidophilus )  key laboratory of dairy science  (klds) 1.0738 had an effective impact on inhibiting β-lactoglobulin (β-lg) allergy. this study further investigated the anti-allergic activity of peptidoglycan (pgn) isolated from klds 1.0738. this study aimed to assess whether toll-like receptor 2 (tlr2)/nf-kappab (nf-κb) signaling ac...