Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson's disease. The syndrome typically develops in male patients with early onset Parkinson's disease, and can occur with orally and subcutaneously admini...

OBJECTIVE To assess the long-term audiological outcome and otological complications of nasopharyngeal carcinoma patients who have received intensity-modulated radiotherapy (IMRT) versus conventional two-dimensional radiotherapy (2 DRT). STUDY DESIGN Prospective study on the audiological outcome and otological complications 5-9 years after radiotherapy. METHODOLOGY Patients had pure-tone aud...

In this paper we analyze the amortized cost of inserts and exact searches in a DRT*, an order preserving scalable distributed data structure able to manage both mono-dimensional and multi-dimensional data. We show that by adding to the DRT* strategy a correction algorithm after split operations, a sequence of m requests of intermixed exact-searches and insertions over a DRT* starting with one e...

Demand responsive transport (DRT), such as shared mini busses are an established form of public transport. Typically, these services operate in areas where demand is low (rural areas), very specific (airport shuttles), or only for certain user groups, such as persons with disabilities. With advances in communication technologies and possible driverless operations in the future, DRT systems may ...

Third-degree burn wounds can cause devastating loss of functionality for patients. As such, platform technologies that allow effective wound management are needed. The purpose this study is to describe the use MatriStem™ urinary bladder matrix (UBM)-based products (MicroMatrix® + Cytal®) (MM+C) and a collagen glycosaminoglycan (GAG) product (Integra® Dermal Regeneration Template (DRT)) (DRT) in...

BACKGROUND Noradrenaline reuptake inhibitors are known to produce analgesia through a spinal action but they also act in the brain. However, the action of noradrenaline on supraspinal pain control regions is understudied. The authors addressed the noradrenergic modulation of the dorsal reticular nucleus (DRt), a medullary pronociceptive area, in the spared nerve injury (SNI) model of neuropathi...

Study Design Prospective study. Objective Surgeons' recommendations for a safe return to driving following cervical and lumbar surgery vary and are based on empirical data. Driver reaction time (DRT) is an objective measure of the ability to drive safely. There are limited data about the effect of cervical and lumbar surgery on DRT. The purpose of our study was to use the DRT to determine when ...

BACKGROUND AND OBJECTIVE To evaluate en face spectral-domain optical coherence tomography (SD-OCT) findings of the outer retinal hard exudates in diabetic macular edema (DME). PATIENTS AND METHODS Exploratory analyses of prospective and consecutive case series. Fifty-five eyes treated with intravitreal ranibizumab (IVR) (Lucentis; Genentech, South San Francisco, CA) for 12 months were classif...

The influential idea by van der Sandt (1992) to treat presuppositions as anaphora in the framework of Discourse Representation Theory (DRT, Kamp and Reyle, 1993) has inspired a lot of debate as well as elaborations of his account. In this paper, we propose an extension of DRT, called Projective DRT, which adds pointers to all DRT referents and conditions, indicating their projection site. This ...

Hedonistic homeostatic dysregulation is a neuropsychological behavioural disorder associated with substance misuse and addiction. The disorder has been recognised as a consequence of dopamine replacement therapy (DRT) in 15 patients with Parkinson’s disease. The syndrome typically develops in male patients with early onset Parkinson’s disease, and can occur with orally and subcutaneously admini...