This paper gives a natural definition of the relaxation time for general single server queues. First, we describe a GI/GI/I queue as a limit of GI/GPH/I queues. Each GI/GPH/I queue is transferred to some equivalent bulk arrival GIx/M/I queue, which is formulated by a spatially homogeneous Markov chain with reflecting barrior at zero. An upper bound, which is easy to calculate, of the relaxation...

Previous studies revealed that phenylhistamines and histaprodifens possess higher potency and affinity at guinea pig histamine H(1)-receptor (gpH(1)R) than at human histamine H(1)-receptor (hH(1)R). However, we recently identified an imidazolylpropylguanidine [N(1)-(3-cyclohexylbutanoyl)-N(2)-[3-(1H-imidazol-4-yl)-propyl]guanidine (UR-AK57)] with higher potency and efficacy at hH(1)R compared w...

Multidrug resistance protein, also referred as P-glycoprotein (P-gp, MDR1; ABCB1) and multidrug resistance-associated protein (MRP) 1 (ABCC1) and 2 (ABCC2) are, thus far, candidates to cause antiepileptic drug (AED) resistance epilepsy. In this study, we investigated P-gp, MRP1 and MRP2 expression, localization and functional activity on cryosections and isolated human brain-derived microvascul...

Long-term consumption of rapidly digestible starches is a major factor associated with diabetes and other metabolic diseases. In this study, cassava starch (CS) was used to investigate interactions between different forms glutenin protein the effect these on in vitro digestibility. First, CS natural (Glu), hydrolysate (GPH), or citric acid modified (CA-Glu) were heat treated. The physicochemica...

To investigate the control at the mRNA level of glycogen metabolism in the cupped oyster Crassostrea gigas, we report in the present paper the cloning and characterization of glycogen phosphorylase and synthase cDNAs (Cg-GPH and Cg-GYS, respectively, transcripts of main enzymes for glycogen use and storage), and their first expression profiles depending on oyster tissues and seasons. A strong e...

We have characterized glycoprotein H (GpH) from bovine adrenal medullary chromaffin granules. Two-dimensional gel electrophoresis was used to purify GpH from an insoluble fraction obtained following extraction of chromaffin granule membranes with lithium diiodosalicylate. The GpH material was recovered from two-dimensional gel spots by concentration and recovery on a one-dimensional gel followe...

For several GPCRs, discrimination between agonism and antagonism is possible on the basis of thermodynamics parameters, such as binding enthalpy and entropy. In this study, we analyze whether agonists and antagonists can also be discriminated thermodynamically at the histamine H(1) receptor (H(1)R). Because previous studies revealed species differences in pharmacology between human H(1)R (hH(1)...

We have recently constructed an integrated programming environment to support programming in Glasgow Parallel Haskell GpH. This paper descibes the construction of several data-intensive parallel programs using the environment. It focuses on a road-traac accident application because it is a real problem with real data, and is the rst non-trivial GpH program to achieve wall-clock speedups | a fac...

This paper investigates the relationship between consumer credits and interest rates in Turkey based on the fractional cointegration approach by using daily observations over the period from 4 January 2002 to 24 December 2010. First, we ignore the possible structural breaks in the series and perform the Geweke and Porter-Hudak (GPH) test on the residuals for fractional cointegration. Second, we...

The pressor response to tracheal intubation is known to be exaggerated in patients with gestational proteinuric hypertension (GPH). We have studied the effect of pretreatment with magnesium sulphate 40 mg kg-1 or 30 mg kg-1 with alfentanil 7.5 micrograms kg-1 on this pressor response in 38 patients with moderate to severe GPH. The magnesium-alfentanil combination produced better control of arte...