1 Department of Endocrinology and Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA, 2 GIM Foundation, Little Rock, AR, USA, 3 Department of Internal Medicine and Hospital Medicine, Christus Trinity Mother Frances Hospital, Tyler, TX, USA, 4 Department of Policy, University of Arkansas for Little Rock, Little Rock, AR, USA, 5 Tutwiler Clinic, Tutwiler, MS, USA...

Monophasic ascending ramp (AR) and descending ramp (DR) waveforms are known to have significantly different defibrillation thresholds. We hypothesized that this difference arises due to differences in mechanisms of arrhythmia induction for the two waveforms. Rabbit hearts (n = 10) were Langendorff perfused, and AR and DR waveforms (7, 20, and 40 ms) were randomly delivered from two line electro...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com and international index of erectile function (IIEF)] were analyzed. Results: Mean age of the patients was 56.9±11.2 years. Mean AR CAG repeat length and serum testosterone levels were 26.7±8.9 and 5.6±2.3 ng/mL, respectively. A Total of 64 men (26.6%) were diagnosed with MS and 22 men we...

INTRODUCTION Beta-adrenoceptors (β-AR) play an important role in the neurohumoral regulation of cardiac function. Three β-AR subtypes (β(1), β(2), β(3)) have been described so far. Total deficiency of these adrenoceptors (TKO) results in cardiac hypotrophy and negative inotropy. TKO represents a unique mouse model mimicking total unselective medical β-blocker therapy in men. Electrophysiologica...

Testosterone (T) and related androgens are performance enhancing drugs (PEDs) abused by some athletes to gain competitive advantage. To monitor unauthorized androgen abuse, doping control programs use mass spectrometry (MS) to detect androgens, synthetic anabolic-androgenic steroids (AASs) and their metabolites in an athlete's urine. AASs of unknown composition will not be detected by these pro...

Therapeutic drug monitoring is an esential tool for a positive management therapy. The prefered laboratory strategy is immunoassay. Due to the cross-reactivity to other components, alternative approaches, such as LC-MS, are continously under investigation. The paper described briefly the main aspects regarding LC-MS apparatus and technique and recent applications on therapeutic drug monitoring,...

Two experiments evaluated the effects of conventional and natural feedlot management systems (MS) on ractopamine-HCl (RAC) response in yearling steers. Feedlot performance, carcass characteristics, skeletal muscle gene expression, and circulating IGF-I concentrations were measured. The conventional system included a combined trenbolone acetate and estradiol implant, Revalor-S (IMP), as well as ...

normal 0 false false false en-us x-none ar-sa radiation therapies are commonly used for malignant or metastatic brain tumors for curative and palliative use. the radiation-induced neurotoxicity includes both parenchymal and vascular damage. here we report the case of a 43-year-old woman who developed multiple sclerosis (ms) 9 months after she underwent the last session of radiotherapy for the d...

The androgen receptor (AR) is a member of the superfamily of nuclear receptors (NRs) that regulate gene expression in a ligand-dependent manner. Selective androgen receptor modulators (SARMs) are ligands that activate AR in a tissue-selective manner to produce unique physiological effects. To investigate the mechanism responsible for SARM tissue-selectivity, the conformation of AR while bound t...

Gold nanorods (GNRs) are of particular interest for biomedical applications due to their unique size-dependent longitudinal surface plasmon resonance band in the visible to near-infrared. Purified GNRs are essential for the advancement of technologies based on these materials. Used in concert, asymmetric-flow field flow fractionation (A4F) and single particle inductively coupled mass spectromet...