We carried out a definition of the species group to which Conus praecellens A. Adams 1854 belongs using a combination of comparative morphological data, molecular phylogeny based on standard genetic markers and toxinological markers. Prior to this work, Conus praecellens was generally postulated to belong to a clade of similarly high-spired, smaller Conusspecies such as Conus pagodus Kiener, 18...

A nano-flow high-resolution screening platform, featuring a parallel chip-based microfluidic bioassay and mass spectrometry coupled to nano-liquid chromatography, was applied to screen animal venoms for nicotinic acetylcholine receptor like (nAChR) affinity by using the acetylcholine binding protein, a mimic of the nAChR. The potential of this microfluidic platform is demonstrated by profiling ...

The afterdischarge of Aplysia bag cell neurons has served as a model system for the study of phosphorylation-mediated changes in neuronal excitability. The nature of the depolarization generating the afterdischarge, however, has remained unclear. We now have found that venom from Conus textile triggers a similar prolonged discharge, and we have identified a slow inward current and corresponding...

The biology of modern Conidae (cone snails)--which includes the hyperdiverse genus Conus--has been intensively studied, but the fossil record of the clade remains poorly understood, particularly within an evolutionary framework. Here, ultraviolet light is used to reveal and characterize the original shell coloration patterns of 28 species of cone snails from three Neogene coral reef-associated ...

We examined the anatomical height and shape of the conus medullaris in 602 cases using magnetic resonance imaging. The peak of the distribution of the conus height was at the middle one-third of L1. The comparison of the conus level had no significant relationships with age or sex, but the juvenile group had more a caudal distribution of the conus level. The shape of the conus medullaris was cl...

To date, only a few reports described the potential factors influencing the position of conus medullaris. One previous study revealed no significant change of conus locations in patients with idiopathic scoliosis; however, the effect of ankylosing spondylitis (AS)-related thoracolumbar kyphosis on conus position remains unexplored. Therefore, we aimed to investigate the variation of conus medul...

There are few reports of electrocardiogram (ECG) changes of conus branch occlusion. A conus branch artery supply to the outflow tract of right ventricle. A conus branch artery is considered as the substrate of Brugada syndrome. We report a case of conus branch occlusion during angioplasty with ST segment elevation in V1-3 like Brugada syndrome ECG. We need to bear in mind that this ECG change m...

1. The anuran conus arteriosus was studied by direct observation of its structure and function and by observing the effects of artificially induced contraction on the pressure pulse in the arterial arches. 2. The beat of the anuran conus was found to close the outlet to the pulmocutaneous arches. The timing of the beat of the conus in the ventricular cycle is variable; early in the cycle the co...

The cone snail is the only invertebrate system in which the vitamin K dependent carboxylase (or γ-carboxylase) and its product γ-carboxyglutamic acid (Gla)1 have been identified. It remains the sole source of structural information of invertebrate γ-carboxylase subtrates. Four novel γcarboxyglutamic acid (Gla)1 containing peptides were purified from the venom of Conus textile and characterized ...