Spontaneous intracranial hypotension (SIH) is a condition caused by spontaneous cerebrospinal fluid (CSF) leakage, resulting in orthostatic headache as the main symptom, but other symptoms such memory loss, nausea, and tinnitus may also be present. Various imaging techniques are used to diagnose SIH, with magnetic resonance myelography being an important tool for detecting leakage site of CSF. ...

We report the isolation and characterization of cDNA clones that encode a protein with the same DNA binding specificity as the immunoglobulin heavy chain enhancer binding protein E (muEBP-E). We call the gene encoding this protein Ig/EBP-1. A fusion protein encoded by the cDNA binds specifically to muEBP-E-binding sites (E sites) in both the IgH enhancer and the VH1 promoter. Sequence analysis ...

BACKGROUND The goal of this study is to extend research on evidence-based practice (EBP) implementation by examining the impact of organizational type (public versus private) and organizational support for EBP on provider attitudes toward EBP and EBP use. Both organization theory and theory of innovation uptake and individual adoption of EBP guide the approach and analyses in this study. We ant...

INTRODUCTION Undergraduate evidence-based practice (EBP) is usually taught through standalone courses and workshops away from clinical practice. This study compared the effects of 2 clinically integrated educational strategies on final year medical students. MATERIALS AND METHODS Final year medical students rotating to the general medicine service for a 2-week internship were randomly assigne...

BACKGROUND Evidence-based practice (EBP) has been proposed as a core competence to improve healthcare quality. The profile of EBP among respiratory therapists (RTs) has not been explored. We investigated how RTs in Taiwan perceive the implementation of EBP. METHODS We surveyed RTs in Taiwan's regional hospitals during a 4-month period in 2011. RESULTS A majority of RTs were aware of EBP (88...

CCAAT/enhancer-binding protein (C/EBP ), a basic leucine zipper transcription factor, is involved in mitotic growth arrest and differentiation. Given that numerous proteins involved in cell cycle regulation are degraded via the ubiquitin-proteasome system, we examined whether the C/EBP protein is degraded via a proteasomal mechanism. In cycloheximide-treated BALB/MK2 keratinocytes we found that...

We developed and implemented an evidence-based practice (EBP) training program to a group of physiotherapists in the Philippines. This qualitative study aimed to explore the perspectives of Filipino physiotherapists regarding EBP and the EBP training provided, and to identify strategies for EBP implementation and sustainability in the Philippines. We used a qualitative descriptive design using ...

Summary C/EBP? represents a paradigm intrinsically disordered transcription factor containing short linear motifs and post-translational modifications (PTM). Unraveling protein interaction networks is prerequisite for understanding the multi-modal functions of in hematopoiesis leukemia. Here, we combined arrayed peptide matrix screening (PRISMA) with BioID to generate an in vivo validated isofo...

C/EBP epsilon is a transcription factor involved in myeloid cell differentiation. Along with C/EBP-alpha, -beta, -gamma, -delta, and -zeta, C/EBP-epsilon belongs to the family of CCAAT/enhancer binding proteins that are implicated in control of growth and differentiation of several cell lineages in inflammation and stress response. We have previously shown that C/EBP-epsilon preferentially bind...