Background: The modeling of Biological Regulatory Networks (BRNs) relies on background knowledge, deriving either from literature and/or the analysis of biological observations. However, with the development of high-throughput data, there is a growing need for methods that automatically generate admissible models. Methods: Our research aim is to provide a logical approach to infer BRNs based on...

background: bacterial superantigen staphylococcal enterotoxins (ses), has stimulated polyclonal t cells irrespective of their antigen specificity, resulted a massive release of cytokines, and suggested that they could be assigned as a candidate of new antitumor agents. recent attempts have done to specifically target superantigens towards tumors, subsequently monoclonal antibodies and tumor-rel...

le besoin croissant de logement et le desir dameliorer la qualite, la securite et la durabilite des batiments, et de diminuer leur prix de revient, ont necessite des recherches etendues dans le domaine des materiaux de la construction. le beton silico-calcaire peut etre considere comme une des reussites remarquables de ces recherches. / le beton silico-calcaire est obtenu par l*acceleation de l...

We have adapted the originally described electronic PCR (e-PCR) algorithm to perform string searches more accurately and much more rapidly than previously possible. Our implementation [multithreaded e-PCR (me-PCR)] runs sufficiently fast to allow even desktop machines to query quickly large genomes with very large genomic element sets. In addition, me-PCR is multithreaded, interprets all IUPAC ...

hnf4a-p.i463vvariant, reported previously in two distinct families suspected of mody-1, is assessed in this report to determine whether it is a mutation or a polymorphism (frequency >1%).200 tunisian healthy people were screened for the presence of hnf4a-p.i463v variant, using rflp-pcr technique and sequencing. then, the frequency of this variant was estimated in the tunisian population and com...

introduction: acinetobacter baumannii is associated with hospital-acquired infections. outer membrane protein a of a.baumannii (abompa) is a well-characterized virulence factor which has important roles in pathogenesis of this bacterium. methods: based on our pcr-sequencing of ompa gene in the clinical isolates, abompa protein can be categorized into two types, named here type-1 and type-2. we ...

In this work, we reported the synthesis and evaluation of antimycobacterial and antifungalactivity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. Thetarget compounds were synthesized in superior yields by reacting thiocarbohydrazide withdifferent aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to bethe most potent derivatives, exhibiting...

lactoferrin (lf) is an iron-binding multi-functional glycoprotein which has numerous physiological functions such as iron transportation, anti-microbial activity and immune response. in this study, different in silico approaches were exploited to investigate lf protein properties in a number of mammalian species. results showed that the iron-binding site, dna and rna-binding sites, signal pepti...

هدف: تحلیل گفتمان‌های پیرامون جانشین­‌پروری در یک دستگاه دولتی.طراحی/ روش­‌شناسی/ رویکرد: تحقیق حاضر به لحاظ رویکرد، کیفی؛ روش نمونه­‌گیری، هدفمند و جمع­‌آوری داده­‌ها عمدتا مصاحبه نیمه ساختاریافته با 13 نفر از مدیران مورد مطالعه بوده است. داده‌­ها، گفتمان انتقادی بهره‌­گیری الگوی فرکلاف طی سه مرحله توصیف، تفسیر تبیین انجام یافته است.یافته‌­های پژوهش: مهم­ترین یافته­‌های بخش استخراج 416 کد مثبت...