The mouse is a valuable model for unravelling the role of hepcidin in iron homeostasis, however, such studies still report hepcidin mRNA levels as a surrogate marker for bioactive hepcidin in its pivotal function to block ferroportin-mediated iron transport. Here, we aimed to assess bioactive mouse Hepcidin-1 (Hep-1) and its paralogue Hepcidin-2 (Hep-2) at the peptide level. To this purpose, Fo...

Hepatocellular carcinoma (HCC) is associated with a high morbidity and mortality due to its high rate of recurrence. However, little is known about the biological characteristics of recurrent HCC cells. A single patient's primary and recurrent HCC-derived cell lines, Hep-11 and Hep-12, respectively, were established by primary culture. These two cell lines have the same hepatitis B virus integr...

The recovery of epididymal spermatozoa, their cryopreservation and posterior use on IVP of bovine embryos, has become an important tool to store genetic material from animals that have died unexpectedly or that have acquired reproductive inability. The present study aimed to evaluate the viability of spermatozoa from epididymides after their incubation on IVF medium supplemented or not with hep...

Scikit-HEP has grown rapidly over the last few years, not just to serve needs of High Energy Physics (HEP) community, but in many ways, Python ecosystem at large. AwkwardArray, boost-histogram/hist, and iminuit are examples libraries that used beyond original HEP focus. In this paper we will look key packages ecosystem, how collection 30+ was developed maintained. Also some software contributio...

Attribute Oriented Induction High level Emerging Pattern (AOI-HEP) is a novel idea which is influenced by Attribute Oriented Induction (AOI) and Emerging Pattern (EP). AOI-HEP discovers patterns such as Total Subsumption HEP (TSHEP), Subsumption Overlapping HEP (SOHEP) and Total Overlapping HEP (TOHEP), include frequent and similar patterns. Mining TSHEP, SOHEP, TOHEP, frequent and similar patt...

The expression levels of the copper transporter P-type adenosine triphosphatase (ATP7B) are known correlate with tumor cell sensitivity to cisplatin. However, the mechanisms underlying cisplatin resistance remained poorly understood. Therefore, in the present study, we treated Hep-2 cells and in-house-developed vincristine-resistant Hep-2v cells with 50, 100, or 200 µM cisplatin and assessed ce...

The rabies virus (RABV) glycoprotein (G) is the principal antigen responsible for the induction of virus neutralizing antibodies (VNA) and is the major modality of protective immunity in animals. A recombinant RABV HEP-Flury strain was generated by reverse genetics to encode two copies of the G-gene (referred to as HEP-dG). The biological properties of HEP-dG were compared to those of the paren...

انتقال ویروس کرونا به داخل سلول از طریق اسپایک‌های انجام می‌شود پس یکی بهترین راه‌های مقابله با سلول‌های بدن، ایجاد اختلال در روند عملکرد است. بنابراین این تحقیق، چگونگی جذب و انرژی پرتوهای رادیواکتیو سارس کووید2، مرس کووید، یوکی کووید توسط ابزار جینت4- دی اِن اِی شبیه‌سازی شده نتایج حاصل پرتودهی اسپایک‌ها یکدیگر مقایسه آن‌جایی که عوامل کاهش ماندگاری می‌باشد، پژوهش سعی است اسپایک ویروس­‌ها به‌وسی...