BACKGROUND Myocardial late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (CE-MRI) of patients with hypertrophic cardiomyopathy (HCM) has been suggested to represent intramyocardial fibrosis and, as such, an adverse prognostic risk factor. We evaluated the characteristics of LGE on CE-MRI and explored whether LGE among patients with HCM was associated with genetic ...

Background In hypertrophic cardiomyopathy (HCM) assessment of late gadolinium enhancement (LGE) is increasingly important as LGE has been demonstrated to be an adverse prognosticator. Manual delineation of LGE after visual assessment is labour-intensive. Automatic quantification is limited by its dependence on signal/noise ratio and varying definition of LGE. Our aim is to assess inter-individu...

BACKGROUND In hypertrophic cardiomyopathy (HCM), the arrhythmic potential associated with a variety of left ventricular myocardial signal intensities evident on contrast-enhanced cardiovascular magnetic resonance with late gadolinium enhancement (LGE) is unresolved. METHODS AND RESULTS In 145 HCM patients (43±15 years old), visually identified areas of LGE in left ventricle were analyzed quan...

OBJECTIVES In the setting of reperfused acute myocardial infarction (AMI), the authors sought to compare prediction of contractile recovery by infarct extracellular volume (ECV), as measured by T1-mapping cardiac magnetic resonance (CMR), with late gadolinium enhancement (LGE) transmural extent. BACKGROUND The transmural extent of myocardial infarction as assessed by LGE CMR is a strong predi...

OBJECTIVE Allograft rejection is still an important cause of morbidity and mortality after heart transplantation (HTx). Many techniques in cardiac magnetic resonance imaging (CMR) were investigated to diagnose acute cellular rejection (ACR). However, there is not enough information about late gadolinium enhancement (LGE) in the myocardium and ACR. METHODS We prospectively analyzed our consecu...

BACKGROUND To determine the prevalence and signal intensity (SI) characteristics of late gadolinium enhancement (LGE) on magnetic resonance imaging (MRI) in takotsubo cardiomyopathy (TC). METHODS AND RESULTS Cine, black-blood T2-weighted and LGE MR images were acquired in 23 patients with TC within 72 h of onset. Wall motion abnormality (WMA), edema and LGE were evaluated with a 16-segment mo...

BACKGROUND Individuals with cardiac sarcoidosis have an increased risk of ventricular arrhythmia and death. Several small cohort studies have evaluated the ability of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (MRI) to predict adverse cardiovascular events. However, studies have yielded inconsistent results, and some analyses were underpowered. Therefore, we sought ...

Background Myocardial fibrosis as detected by late gadolinium enhancement (LGE) has been linked to adverse prognosis in several cardiovascular diseases. In aortic stenosis, LGE has been linked to worse systolic function and prognosis. In aortic regurgitation (AR), LGE has only been described in small experimental and clinical trials. Objectives: To evaluate the presence of LGE, its relation to ...

Background Late gadolinium enhancement (LGE) is used to evaluate fibrosis of the left atrium (LA) in subjects with atrial fibrillation (AF). LA fibrosis by LGE has been shown to correlate with LA volumes. However, within AF subjects, the association of mitral regurgitation (MR) with LA LGE is not well described. Pathological studies have demonstrated atrial fibrosis and tissue disorganization i...

BACKGROUND Patients with Duchenne muscular dystrophy exhibit progressive cardiac and skeletal muscle dysfunction. Based on prior data, cardiac dysfunction in Duchenne muscular dystrophy patients may be influenced by myocardial fibrosis and steroid therapy. We examined the longitudinal relationship of myocardial fibrosis and ventricular dysfunction using cardiac magnetic resonance in a large Duc...